Evidence map›Paper›PMID 33441099›Full record

Trial reportBMC geriatrics2021

Acute effects of strength and endurance exercise on serum BDNF and IGF-1 levels in older men.

Hamid Arazi, Parvin Babaei, Makan Moghimi, Abbas Asadi

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC geriatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 3 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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  11. Novel biomarkers for sarcopenia: a narrative review.Journal of orthopaedic surgery and research · 2026
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  17. Physical Activity, Exerkines, and Their Role in Cancer Cachexia.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Hamid AraziDepartment of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran. hamidarazi@yahoo.com.ORCID 0000-0002-1594-6515
Parvin BabaeiCellular and Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Makan MoghimiDepartment of Sport Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran.
Abbas AsadiDepartment of Physical Education and Sport Sciences, Payame Noor University, Tehran, Iran.
Guilan University of Medical Sciences · IRIslamic Azad University Rasht Branch · IRPayame Noor University · IRUniversity of Guilan · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRegarding an important effects of physical exercise on brain function in elders, the aim of this study was to examine the effects of strength and endurance exercise on brain neurobiological factors in older men.

methodsThirty older men volunteered to participate in this study and were randomly assigned to strength, endurance and control groups. The subjects in strength group performed two circuits of resistance exercise (6 exercises with 10 repetition of 65-70% of one repetition maximum), while endurance group performed 30 min running with 65-70% of maximal heart rate. Blood was obtained pre and post-exercise to determine changes in serum BDNF, IGF-1 and platelets.

resultsAfter exercise, both the strength and endurance groups showed significant increases in serum BDNF and IGF-1 concentrations and platelets at post-exercise and in comparison to control group (p < 0.05). In addition, no statistically significant differences were detected between the strength and endurance groups at post-exercise.

conclusionOur findings indicate that both the strength and endurance interventions are effective in elevating BDNF, IGF-1, and platelets, without significant differences between them.

Indexed as

Brain-Derived Neurotrophic FactorInsulin-Like Growth Factor IAgedExerciseExercise TherapyHumansMalePhysical EnduranceBDNF protein, humanBrain-Derived Neurotrophic FactorIGF1 protein, humanInsulin-Like Growth Factor IBrain agingNeurotrophic factorPhysical exercise

Identifiers

PMID33441099
PMCPMC7807435
OpenAlexW3119764478

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.