ArticleBMC cardiovascular disorders2021
Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression.
Article in BMC cardiovascular disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Association Between the Number of Metabolic Syndrome Components and Markers of Subclinical Vascular Damage: A Retrospective Cross-Sectional Study.Journal of clinical medicine · 2026Article
- From ASCOT to Asia: A More Active and Successful Approach in Preventing Cardiovascular Disease.Acta Cardiologica Sinica · 2026Review
- Risk prediction score and equation for progression of arterial stiffness using Japanese longitudinal health examination data.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- LDL-C/HDL-C ratio as a predictor of atherosclerosis in the Japanese population: insights from a cross-sectional study.BMC cardiovascular disorders · 2025Article
- Development of an interpretable machine learning model for early prediction of aortic stiffness risk in health examination populations.Frontiers in cardiovascular medicine · 2025Article
- Serum Malondialdehyde-Modified Low-Density Lipoprotein Level May Be a Biomarker Associated with Aortic Stiffness Among Patients Undergoing Peritoneal Dialysis.Life (Basel, Switzerland) · 2024Article
- Associations between insulin resistance indices and subclinical atherosclerosis: A contemporary review.American journal of preventive cardiology · 2024Review
- The Impact of the Blood Lipids Levels on Arterial Stiffness.Journal of cardiovascular development and disease · 2023Review
- Genetic and biomarker modulation of arterial stiffness change in the SardiNIA population cohort.Frontiers in epidemiology · 2023Article
- SAGE Score in Normotensive and Pre-Hypertensive Patients: A Proof of Concept.Arquivos brasileiros de cardiologia · 2023Article
- Arterial Stiffness Assessment by Pulse Wave Velocity in Patients with Metabolic Syndrome and Its Components: Is It a Useful Tool in Clinical Practice?International journal of environmental research and public health · 2022Review
- Dyslipidemia Increases the Risk of Incident Hypertension in a Large Taiwanese Population Follow-Up Study.Nutrients · 2022Article
- Arterial Stiffness Determinants for Primary Cardiovascular Prevention among Healthy Participants.Journal of clinical medicine · 2022Article
- Association Between Lipids and Arterial Stiffness for Primary Cardiovascular Prevention in a General Middle-Aged European Population.Frontiers in cardiovascular medicine · 2022Article
- Association of Dietary Patterns with Cardiovascular and Kidney Phenotypes in an Uruguayan Population Cohort.Nutrients · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDyslipidemia contributes to the development and progression of arterial stiffness. We aimed to identify the most informative measures of serum lipids and their calculated ratios in terms of arterial stiffness progression risk.
methodsTotal cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and brachial-ankle pulse wave velocity (baPWV) of 659 healthy males (47.4 ± 10.7 years) were measured at baseline. Values for non-HDL-C, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, and non-HDL-C/HDL-C were calculated. BaPWV was re-performed after 4.1 years follow-up. Elevated baPWV was defined as baPWV ≥ 1400 cm/s.
resultsOver the follow-up period, the mean baPWV value increased from 1340 cm/s to 1410 cm/s, and 331 individuals increased/persisted with high baPWV (outcome 1). Among the 448 subjects who had normal baseline baPWV, 100 incident elevated baPWV occurred (outcome 2). Only baseline logTG (OR 1.64 [95% CI: 1.14-2.37] for outcome 1; 1.89 [1.14-3.17] for outcome 2) and logTG/HDL-C (1.54 [1.15-2.10] for outcome 1; 1.60 [1.05-2.45] for outcome 2) were significantly associated with arterial stiffness progression after adjusting for confounding factors. Adding logTG or logTG/HDL-C to age and blood pressure improved the accuracy of risk predictions for arterial stiffness progression. These associations remained significant when lipids were analyzed as categorical variables.
conclusionsBaseline serum TG and TG/HDL-C were independently associated with increases in/persistently high baPWV and incident elevated baPWV, and they performed more effectively than other lipid variables in identifying healthy men at high risk of arterial stiffness progression.
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