Evidence map›Paper›PMID 33441029›Full record

ArticleJournal of the American Heart Association2021

Long-Term Survival of Patients With Left Ventricular Noncompaction.

Vaibhav R Vaidya, Melissa Lyle, William R Miranda, Medhat Farwati, Ameesh Isath, Sri Harsha Patlolla, David O Hodge, Samuel J Asirvatham, Suraj Kapa, Abhishek J Deshmukh and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

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  16. Searching for genetic determinants for left ventricular non-compaction.Quantitative imaging in medicine and surgery · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Vaibhav R VaidyaDepartment of Cardiovascular Diseases Mayo Clinic Rochester MN.
Melissa LyleDepartment of Cardiovascular Diseases Mayo Clinic Rochester MN.
William R MirandaDepartment of Cardiovascular Diseases Mayo Clinic Rochester MN.
Medhat FarwatiDepartment of Cardiovascular Diseases Mayo Clinic Rochester MN.
Ameesh IsathDepartment of Cardiovascular Diseases Mayo Clinic Rochester MN.
Sri Harsha PatlollaDepartment of Cardiovascular Diseases Mayo Clinic Rochester MN.
David O HodgeDepartment of Cardiovascular Diseases Mayo Clinic Jacksonville FL.
Samuel J AsirvathamDepartment of Cardiovascular Diseases Mayo Clinic Rochester MN.
Suraj KapaDepartment of Cardiovascular Diseases Mayo Clinic Rochester MN.
Abhishek J DeshmukhDepartment of Cardiovascular Diseases Mayo Clinic Rochester MN.
Thomas A FoleyDepartment of Radiology Mayo Clinic Rochester MN.
Hector I MichelenaDepartment of Cardiovascular Diseases Mayo Clinic Rochester MN.
Heidi M ConnollyDepartment of Cardiovascular Diseases Mayo Clinic Rochester MN.
Rowlens M MelduniDepartment of Cardiovascular Diseases Mayo Clinic Rochester MN.
Mayo Clinic in Arizona · USMayo Clinic · USJacksonville College · US

Funding

The Role of Autoimmune Mechanisms in the Pathogenesis of Atrial FibrillationK01HL135288 · NHLBI · MAYO CLINIC ROCHESTER · PI MELDUNI, ROWLENS MICHEL · 2017 to 2021
$854k
NHLBI NIH HHS K01 HL135288
6 · The paper itself

Abstract

Background The prognosis of left ventricular noncompaction (LVNC) remains elusive despite its recognition as a clinical entity for >30 years. We sought to identify clinical and imaging characteristics and risk factors for mortality in patients with LVNC. Methods and Results 339 adults with LVNC seen between 2000 and 2016 were identified. LVNC was defined as end-systolic noncompacted to compacted myocardial ratio >2 (Jenni criteria) and end-diastolic trough of trabeculation-to-epicardium (X):peak of trabeculation-to-epicardium (Y) ratio <0.5 (Chin criteria) by echocardiography; and end-diastolic noncompacted:compacted ratio >2.3 (Petersen criteria) by magnetic resonance imaging. Median age was 47.4 years, and 46% of patients were female. Left ventricular ejection fraction <50% was present in 57% of patients and isolated apical noncompaction in 48%. During a median follow-up of 6.3 years, 59 patients died. On multivariable Cox regression analysis, age (hazard ratio [HR] 1.04; 95% CI, 1.02-1.06), left ventricular ejection fraction <50% (HR, 2.37; 95% CI, 1.17-4.80), and noncompaction extending from the apex to the mid or basal segments (HR, 2.11; 95% CI, 1.21-3.68) were associated with all-cause mortality. Compared with the expected survival for age- and sex-matched US population, patients with LVNC had reduced overall survival (

Indexed as

Heart Defects, CongenitalStroke VolumeAge FactorsEchocardiographyFemaleHumansMagnetic Resonance Imaging, CineMaleMiddle AgedMortalityPrognosisRetrospective StudiesSex FactorsSurvival AnalysisUnited StatesVentricular Function, Leftejection fractionmortalitynoncompactionprognosissurvival

Identifiers

PMID33441029
PMCPMC7955291
OpenAlexW3119095799

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.