Evidence map›Paper›PMID 33440917›Full record

ArticleDiabetes & metabolism journal2021

Level of Organochlorine Pesticide in Prediabetic and Newly Diagnosed Diabetes Mellitus Patients with Varying Degree of Glucose Intolerance and Insulin Resistance among North Indian Population.

Shipra Tyagi, Brijesh Kumar Mishra, Tusha Sharma, Neha Tawar, Abdul Jamil Urfi, Basu Dev Banerjee, Sri Venkata Madhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes & metabolism journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shipra TyagiDepartment of Environmental Studies, University of Delhi (North Campus), Delhi, India.
Brijesh Kumar MishraDepartment of Endocrinology, University College of Medical Sciences, University of Delhi, Delhi, India.
Tusha SharmaEnvironmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry, University College of Medical Sciences, University of Delhi, Delhi, India.
Neha TawarEnvironmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry, University College of Medical Sciences, University of Delhi, Delhi, India.
Abdul Jamil UrfiDepartment of Environmental Studies, University of Delhi (North Campus), Delhi, India.
Basu Dev BanerjeeEnvironmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry, University College of Medical Sciences, University of Delhi, Delhi, India.
Sri Venkata MadhuDepartment of Endocrinology, University College of Medical Sciences, University of Delhi, Delhi, India.
University of Delhi · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOrganochlorine pesticides (OCPs) exposure may induce an endocrine disruption which may lead to the risk of developing diabetes through alteration and disturbance of glucose metabolism, insulin resistance, and destruction of β-cells. The present study determines the recent trend of OCPs residue in blood samples and their association with the known risk factors responsible for developing the risk of diabetes among the North Indian population.

methodsBlood sample of 300 patients (100 each of normal glucose tolerance [NGT], prediabetes and newly detected diabetes mellitus [DM]) between the age group of 30 to 70 years were collected. OCPs residue in whole blood samples was analyzed by using gas chromatography equipped with a 63Ni selective electron capture detector.

resultsSignificantly higher levels of β-hexachlorocyclohexane (HCH), dieldrin, and p,p'-dichloro-diphenyl-dichloroethylene (DDE) were found in the prediabetes and newly detected DM groups as compared to NGT group. Insulin resistance showed to be significantly positive correlation with β-HCH and dieldrin. Also, fasting and postprandial glucose levels were significantly positively correlated with levels of β-HCH, dieldrin, and p,p'-DDE. Further, when OCPs level was adjusted for age and body mass index (BMI), it was found that β-HCH, dieldrin, and p,p'-DDE levels in blood increases the risk of diabetes by 2.70, 2.83, and 2.55 times respectively. Moreover, when we adjust OCPs level based on BMI categories (BMI <23, ≥23, and ≤25, and >25 kg/m2); β-HCH and p,p'-DDE showed a significant risk of developing newly detected DM with BMI >25 and ≥23 and ≤25 kg/m2.

conclusionThe OCPs level present in the environment may be responsible for biological, metabolic, and endocrine disruptions within the human body which may increase the risk of developing newly detected DM. Hence, OCPs exposure can play a crucial role in the etiology of diabetes.

Indexed as

Glucose IntoleranceHydrocarbons, ChlorinatedInsulin ResistancePesticidesPrediabetic StateAdultAgedHumansMiddle AgedHydrocarbons, ChlorinatedPesticidesBody mass indexDiabetes mellitusDichlorodiphenyl dichloroethyleneDieldrinHexachlorocyclohexaneInsulin resistancePrediabetic state

Identifiers

PMID33440917
PMCPMC8369217
OpenAlexW3120271699

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.