Evidence map›Paper›PMID 33440852›Full record

ArticleBiosensors2021

Detection of Hypoxanthine from Inosine and Unusual Hydrolysis of Immunosuppressive Drug Azathioprine through the Formation of a Diruthenium(III) System.

Marta Orts-Arroyo, Isabel Castro, José Martínez-Lillo

Abstract read
In one paragraph

Article in Biosensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marta Orts-ArroyoInstituto de Ciencia Molecular (ICMol), Universitat de València, c/ Catedrático José Beltrán 2, Paterna, 46980 València, Spain.
Isabel CastroInstituto de Ciencia Molecular (ICMol), Universitat de València, c/ Catedrático José Beltrán 2, Paterna, 46980 València, Spain.ORCID 0000-0002-6046-3571
José Martínez-LilloInstituto de Ciencia Molecular (ICMol), Universitat de València, c/ Catedrático José Beltrán 2, Paterna, 46980 València, Spain.ORCID 0000-0003-1107-2344

Funding

Ministerio de Ciencia, Innovación y Universidades Project PID2019-109735GB-I00VLC-BIOCLINIC Program (2017) [Subprogram A] Project 02-2017-A
6 · The paper itself

Abstract

Hypoxanthine (hpx) is an important molecule for both biochemistry research and biomedical applications. It is involved in several biological processes associated to energy and purine metabolism and has been proposed as a biomarker for a variety of disease states. Consequently, the discovery and development of systems suitable for the detection of hypoxanthine is pretty appealing in this research field. Thus, we have obtained a stable diruthenium (III) compound in its dehydrated and hydrated forms with formula [{Ru(µ-Cl)(µ-hpx)}

Indexed as

AzathioprineHydrolysisHypoxanthineImmunosuppressive AgentsInosineLimit of DetectionMicroscopy, Electron, ScanningModels, MolecularMolecular ConformationPurinesRutheniumX-Ray DiffractionAzathioprineHypoxanthineImmunosuppressive AgentsInosinepurinePurinesRuthenium6-mercaptopurineazathioprinebiomarkerhypoxanthineinosineruthenium

Identifiers

PMID33440852
PMCPMC7827764

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.