Evidence map›Paper›PMID 33440802›Full record

ArticleBiomedicines2021

Hypertrophy and Insulin Resistance of Epicardial Adipose Tissue Adipocytes: Association with the Coronary Artery Disease Severity.

Natalia V Naryzhnaya, Olga A Koshelskaya, Irina V Kologrivova, Olga A Kharitonova, Vladimir V Evtushenko, Alla A Boshchenko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Natalia V NaryzhnayaCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Science, 634050 Tomsk, Russia.ORCID 0000-0003-2264-1928
Olga A KoshelskayaCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Science, 634050 Tomsk, Russia.
Irina V KologrivovaCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Science, 634050 Tomsk, Russia.
Olga A KharitonovaCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Science, 634050 Tomsk, Russia.
Vladimir V EvtushenkoCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Science, 634050 Tomsk, Russia.
Alla A BoshchenkoCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Science, 634050 Tomsk, Russia.
Tomsk National Research Medical Center · RU

Funding

Ministry of Science and Higher Education of the Russian Federation AAAA-A15-115123110026-3
6 · The paper itself

Abstract

Changes in the structural and functional characteristics of the epicardial adipose tissue (EAT) are recognized as one of the factors in the development of cardiometabolic diseases. However, the generally accepted quantitative assessment of the accumulation of EAT does not reflect the size of adipocyte and presence of adipocyte hypertrophy in this fat depot. Overall contribution of adipocyte hypertrophy to the development and progression of coronary atherosclerosis remains unexplored. Objective: To compare the morphological characteristics of EAT adipocyte and its sensitivity to insulin with the CAD severity, as well as to identify potential factors involved in the realization of this relationship. The present study involved 24 patients (m/f 16/8) aged 53-72 years with stable CAD, who underwent coronary artery bypass graft surgery. Adipocytes were isolated enzymatically from EAT explants obtained during the operation. The severity of CAD was assessed by calculating the Gensini score according to selective coronary angiography. Insulin resistance of EAT adipocytes was evaluated by reactivity to insulin. In patients with an average size of EAT adipocytes equal to or exceeding the median (87 μm) the percentage of hypertrophic adipocytes was twice as high as in patients in whom the average size of adipocytes was less than 87 μm. This group of patients was also characterized by the higher rate of the Gensini score, lower adiponectin levels, and more severe violation of carbohydrate metabolism. We have revealed direct nonparametric correlation between the size of EAT adipocytes and the Gensini score (r

Indexed as

adipokinesCAD severityepicardial adipose tissuehypertrophy of adipocytesinsulin resistance

Identifiers

PMID33440802
PMCPMC7827040
OpenAlexW3118597060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.