Evidence map›Paper›PMID 33440749›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Towards Routine Implementation of Liquid Biopsies in Cancer Management: It Is Always Too Early, until Suddenly It Is Too Late.

Maarten J IJzerman, Jasper de Boer, Arun Azad, Koen Degeling, Joel Geoghegan, Chelsee Hewitt, Frédéric Hollande, Belinda Lee, Yat Ho To, Richard W Tothill and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06105177 (Implementation of Up-front ctDNA Analysis Into Lung Cancer Care and Development of Liquid Biopsy-based Decision Support Models - the Lungmarker² Study), which is not on this map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06105177 recruitingnot on this mapstarted 2023, after this paper: background citation

Implementation of Up-front ctDNA Analysis Into Lung Cancer Care and Development of Liquid Biopsy-based Decision Support Models - the Lungmarker² Study

Typeobservational_patient_registrySponsorCatharina Ziekenhuis EindhovenRan2023 to 2026Enrolled800ConditionsLung Cancer
3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
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  10. A scoping review of factors influencing the implementation of liquid biopsy for cancer care.Journal of experimental & clinical cancer research : CR · 2025
    Article
  11. Article
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  13. Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maarten J IJzermanFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne Centre for Cancer Research, Parkville, VIC 3000, Australia.ORCID 0000-0001-5788-5805
Jasper de BoerVictorian Comprehensive Cancer Centre, Parkville, VIC 3050, Australia.ORCID 0000-0002-3220-8776
Arun AzadDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Parkville, VIC 3000, Australia.
Koen DegelingFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne Centre for Cancer Research, Parkville, VIC 3000, Australia.ORCID 0000-0001-7487-2491
Joel GeogheganIllumina Inc., San Diego, CA 92122, USA.
Chelsee HewittDepartment of Pathology, Peter MacCallum Cancer Centre, Parkville, VIC 3000, Australia.
Frédéric HollandeFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne Centre for Cancer Research, Parkville, VIC 3000, Australia.ORCID 0000-0002-7046-8392
Belinda LeeDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Parkville, VIC 3000, Australia.ORCID 0000-0002-0947-9834
Yat Ho ToDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Parkville, VIC 3000, Australia.
Richard W TothillFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne Centre for Cancer Research, Parkville, VIC 3000, Australia.
Gavin WrightDepartment of Surgery, St. Vincents Hospital, Melbourne, VIC 3065, Australia.
Jeanne TieDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Parkville, VIC 3000, Australia.
Sarah-Jane DawsonFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne Centre for Cancer Research, Parkville, VIC 3000, Australia.ORCID 0000-0002-8276-0374

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blood-based liquid biopsies are considered a new and promising diagnostic and monitoring tool for cancer. As liquid biopsies only require a blood draw, they are non-invasive, potentially more rapid and assumed to be a less costly alternative to genomic analysis of tissue biopsies. A multi-disciplinary workshop (

Indexed as

biomarkerscancercancer surveillanceCTCctDNAearly detectiongenomicshealth economicshealth services researchliquid biopsyminimal residual disease

Identifiers

PMID33440749
PMCPMC7826562

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.