Evidence map›Paper›PMID 33440675›Full record

ArticleNutrients2021

Genistein Reduces the Risk of Local Mammary Cancer Recurrence and Ameliorates Alterations in the Gut Microbiota in the Offspring of Obese Dams.

Fabia de Oliveira Andrade, Fang Liu, Xiyuan Zhang, Mariana Papaleo Rosim, Caroline Dani, Idalia Cruz, Thomas T Y Wang, William Helferich, Robert W Li, Leena Hilakivi-Clarke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Fabia de Oliveira AndradeDepartment of Oncology, Georgetown University, Washington, DC 20057, USA.
Fang LiuCollege of Food Science and Engineering, Ocean University of China, Qingdao 266555, China.
Xiyuan ZhangDepartment of Oncology, Georgetown University, Washington, DC 20057, USA.ORCID 0000-0001-9949-5258
Mariana Papaleo RosimDepartment of Oncology, Georgetown University, Washington, DC 20057, USA.
Caroline DaniDepartment of Oncology, Georgetown University, Washington, DC 20057, USA.ORCID 0000-0003-0046-7148
Idalia CruzDepartment of Oncology, Georgetown University, Washington, DC 20057, USA.
Thomas T Y WangUnited States Department of Agriculture, Beltsville Human Nutrition Center, Diet, Genomics and Immunology Laboratory, Beltsville, MD 20705, USA.ORCID 0000-0003-2299-9452
William HelferichDepartment of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL 1801, USA.
Robert W LiUnited States Department of Agriculture, Agricultural Research Service, Animal Genomics and Improvement Laboratory, Beltsville, MD 20705, USA.ORCID 0000-0001-9220-7049
Leena Hilakivi-ClarkeDepartment of Oncology, Georgetown University, Washington, DC 20057, USA.
Georgetown University · USAgricultural Research Service · USOcean University of China · CNUnited States Department of Agriculture · USUniversity of Illinois Urbana-Champaign · US

Funding

American Institute for Cancer Research Grant to Leena Hilakivi-ClarkeNIH HHS P30-CA51008NIH HHS R01-CA164384
6 · The paper itself

Abstract

The risk of recurrence of estrogen receptor-positive breast cancer remains constant, even 20 years after diagnosis. Recurrence may be more likely in patients pre-programmed for it already in the womb, such as in the daughters born to obese mothers. Maternal obesity persistently alters offspring's gut microbiota and impairs tumor immune responses. To investigate if the gut dysbiosis is linked to increased risk of mammary cancer recurrence in the offspring of obese rat dams, we fed adult offspring genistein which is known to have beneficial effects on the gut bacteria. However, the effects of genistein on breast cancer remain controversial. We found that genistein intake after tamoxifen response prevented the increased risk of local recurrence in the offspring of obese dams but had no effect on the control offspring. A significant increase in the abundance of inflammatory

Indexed as

AnimalsFemaleGastrointestinal MicrobiomeGenisteinMammary Neoplasms, AnimalObesityPregnancyPrenatal Exposure Delayed EffectsRatsRats, Sprague-DawleyGenisteinantiestrogen resistancebreast cancergenisteingut microbiotatamoxifen therapytumor immune genes

Identifiers

PMID33440675
PMCPMC7827465
OpenAlexW3119621297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.