ArticlePathogens (Basel, Switzerland)2021
Systemic Inflammatory Index Is a Novel Predictor of Intubation Requirement and Mortality after SARS-CoV-2 Infection.
Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- Comparison of Severe COVID-19 Outcomes in Vaccinated and Unvaccinated Patients, with and Without Diabetes Mellitus in a Romanian Tertiary Healthcare Pneumology Hospital-A Retrospective Study.International journal of molecular sciences · 2026Article
- Comparative Analysis of Systemic Inflammatory Biomarkers Across Multiple Antiseizure Medications: A Single-Center Retrospective Cohort Study of 1782 Patients.Journal of clinical medicine · 2025Article
- Combined Systemic Immune-Inflammation Index-Prognostic Nutritional Index Score in Evaluating the Prognosis of Patients with Severe Community-Acquired Pneumonia.Journal of inflammation research · 2025Article
- Comparison of Platelet Indices, Lymphocyte, and Systemic Inflammation Indices on Days 1 and 8 in Surviving and Non-Surviving COVID-19 Patients at Hasan Sadikin General Hospital, Bandung, Indonesia.Journal of blood medicine · 2025Article
- Immune Cell-Based versus Albumin-Based Ratios as Outcome Predictors in Critically Ill COVID-19 Patients.Journal of inflammation research · 2025Article
- Article
- Evaluation of malnutrition by objective nutritional indexes and predictors in hospitalized patients with COVID-19.Journal of clinical biochemistry and nutrition · 2024Article
- Prognostic Nutritional Index (PNI) and Systemic Immune-Inflammatory Index (SII) as markers of severity among patients having COVID-19 infection.Journal of family medicine and primary care · 2024Article
- Predictivity of the Prognostic Nutritional Index and Systemic Inflammation Index for All-Cause In-Hospital Mortality in Geriatric and Adult COVID-19 Inpatients.Journal of clinical medicine · 2024Article
- Diagnostic value of systemic immune inflammation index in acute appendicitis and complicated appendicitis in pregnant patients.Langenbeck's archives of surgery · 2024Article
- Predictive value of systemic inflammatory index (SII) for the time to negative nucleic acid conversion in patients with mild COVID-19 by the omicron wave.Frontiers in medicine · 2024Article
- Systemic immune inflammation index as a predictor of disease severity in tetanus patients: A retrospective observational study.PloS one · 2024Observational
- Assessment of hematologic indices for diagnosis in juvenile systemic lupus erythematosus.Reumatologia · 2024Article
- Hematological Composite Scores in Patients with Inflammatory Bowel Disease.Journal of clinical medicine · 2023Article
- The predictive role of biochemical markers on outcomes of severe COVID-19 patients admitted to intensive care unit.Journal of medical biochemistry · 2023Article
- A diagnostic model based on routine blood examination for serious bacterial infections in neonates-a cross-sectional study.Epidemiology and infection · 2023Article
- New Generation of Systemic Inflammatory Markers for Respiratory Syncytial Virus Infection in Children.Viruses · 2023Article
- Potential Benefits of Omega-3 Polyunsaturated Fatty Acids (N3PUFAs) on Cardiovascular Health Associated with COVID-19: An Update for 2023.Metabolites · 2023Review
- Evaluation of systemic immune-inflammation index efficacy in predicting complicated appendicitis in pediatric emergency department.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2023Article
- Extracting relevant predictive variables for COVID-19 severity prognosis: An exhaustive comparison of feature selection techniques.PloS one · 2023Article
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronavirus disease 2019 (COVID-19), with an increasing number of deaths worldwide, has created a tragic global health and economic emergency. The disease, caused by severe acute respiratory syndrome coronavirus 2019 (SARS-CoV-19), is a multi-system inflammatory disease with many of COVID-19-positive patients requiring intensive medical care due to multi-organ failures. Biomarkers to reliably predict the patient's clinical cause of the virus infection, ideally, to be applied in point of care testing or through routine diagnostic approaches, are highly needed. We aimed to probe if routinely assessed clinical lab values can predict the severity of the COVID-19 course. Therefore, we have retrospectively analyzed on admission laboratory findings in 224 consecutive patients from four hospitals and show that systemic immune inflammation index (SII) is a potent marker for predicting the requirement for invasive ventilator support and for worse clinical outcome of the infected patient. Patients' survival and severity of SARS-CoV-2 infection could reliably be predicted at admission by calculating the systemic inflammatory index of individual blood values. We advocate this approach to be a feasible and easy-to-implement assay that may be particularly useful to improve patient management during high influx crisis. We believe with this work to contribute to improving infrastructure availability and case management associated with COVID-19 pandemic hurdles.
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