ArticleJournal of the American Academy of Child and Adolescent Psychiatry2021
Phasic Versus Tonic Irritability: Differential Associations With Attention-Deficit/Hyperactivity Disorder Symptoms.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Pooled it
- Foster Care Leads to Lower Irritability Among Adolescents with a History of Early Psychosocial Deprivation.Research on child and adolescent psychopathology · 2024Trial
- Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2026Review
- Domain Generality or Domain Specificity? The Associations Between Family Adversity, Irritability, and Psychopathology in Adolescence.Child psychiatry and human development · 2026Article
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- Associations of Tonic and Phasic Irritability With Psychopathology Subfactors of the Hierarchical Taxonomy of Psychopathology.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- An Investigation of Inhibitory Control as a Mechanism Differentiating Tonic and Phasic Irritability.Child psychiatry and human development · 2026Article
- Network relationships between emotional dysregulation and ADHD symptoms: an investigation of 13,207 clinical children and adolescents.European child & adolescent psychiatry · 2026Article
- Psychometric properties and cross-cultural adaptation of the Japanese version of the Affective Reactivity Index: A community-based study of adolescent irritability.PCN reports : psychiatry and clinical neurosciences · 2025Article
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- Concurrent and longitudinal neurostructural correlates of irritability in children.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Modeling Shared and Specific Variances of Irritability, Inattention, and Hyperactivity Yields Novel Insights Into White Matter Perturbations.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- Sleepless nights, sour moods: daily sleep-irritability links in a pediatric clinical sample.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Momentary Dynamics Implicate Emotional Features in the ADHD Phenotype.Research on child and adolescent psychopathology · 2024Article
- Autistic Symptoms, Irritability, and Executive Dysfunctions: Symptom Dynamics from Multi-Network Models.Journal of autism and developmental disorders · 2024Article
- Is irritability multidimensional: Psychometrics of The Irritability and Dysregulation of Emotion Scale (TIDES-13).European child & adolescent psychiatry · 2024Article
- Early Predictors and Concurrent Correlates of Tonic and Phasic Irritability in Adolescence.Research on child and adolescent psychopathology · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveIrritability is a multifaceted construct in pediatric psychopathology. It has been conceptualized as having a phasic dimension and a tonic dimension. Disruptive mood dysregulation disorder is defined by the presence of both dimensions. Severe irritability, or disruptive mood dysregulation disorder, is highly comorbid with attention-deficit/hyperactivity disorder (ADHD). However, it is unknown whether the presence of ADHD modulates the expression of phasic and tonic irritability.
methodA data-driven, latent variable approach was used to examine irritability and ADHD symptoms in a transdiagnostic pediatric sample (N = 489) with primary disruptive mood dysregulation disorder, ADHD, subclinical irritability symptoms, or no diagnosis. Using latent profile analyses, we identified 4 classes: high levels of both irritability and ADHD symptoms, high levels of irritability and moderate levels of ADHD symptoms, moderate levels of irritability and high levels of ADHD symptoms, and low levels of both irritability and ADHD symptoms. Confirmatory factor analysis operationalized phasic irritability and tonic irritability.
resultsAs expected, the 2 latent classes characterized by high overall irritability exhibited the highest levels of both phasic and tonic irritability. However, between these 2 high irritability classes, highly comorbid ADHD symptoms were associated with significantly greater phasic irritability than were moderately comorbid ADHD symptoms. In contrast, the 2 high irritability groups did not differ on levels of tonic irritability.
conclusionThese findings suggest that phasic, but not tonic, irritability has a significant association with ADHD symptoms and that phasic and tonic might be distinct, though highly related, irritability dimensions. Future research should investigate potential mechanisms underlying this differential association.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.