ArticleAmerican journal of human genetics2021
Disentangling selection on genetically correlated polygenic traits via whole-genome genealogies.
Article in American journal of human genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Genomic insights into natural selection in recent human history.Nature reviews. Genetics · 2026Review
- Genetic prediction with ARG-powered linear algebra.Genetics · 2026Article
- Optimizing genomic sampling for demographic and epidemiological inference with Markov decision processes.Genetics · 2026Article
- Multivariate genome-wide association analysis of dyslexia and quantitative reading skill improves gene discovery.Translational psychiatry · 2025Article
- Article
- Evaluating ARG-estimation methods in the context of estimating population-mean polygenic score histories.Genetics · 2025Article
- Inference and applications of ancestral recombination graphs.Nature reviews. Genetics · 2025Review
- Evaluating ARG-estimation methods in the context of estimating population-mean polygenic score histories.bioRxiv : the preprint server for biology · 2024Article
- Article
- Genetic interactions and pleiotropy in metabolic diseases: Insights from a comprehensive GWAS analysis.Journal of cellular and molecular medicine · 2024Article
- Neuroimaging genomics as a window into the evolution of human sulcal organization.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The Promise of Inferring the Past Using the Ancestral Recombination Graph.Genome biology and evolution · 2024Article
- Combination Therapy: A New Tool for the Management of Obesity.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations.Nature · 2024Article
- Unveiling recent and ongoing adaptive selection in human populations.PLoS biology · 2024Article
- Signatures of adaptation in myopia-related genes on the sunlight exposure hypothesis.Journal of physiological anthropology · 2023Article
- Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies.Nature genetics · 2023Article
- Biobank-scale inference of ancestral recombination graphs enables genealogical analysis of complex traits.Nature genetics · 2023Article
- Locus-level antagonistic selection shaped the polygenic architecture of human complex diseases.Human genetics · 2022Article
- Mosaic patterns of selection in genomic regions associated with diverse human traits.PLoS genetics · 2022Article
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4 authors.
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Abstract
We present a full-likelihood method to infer polygenic adaptation from DNA sequence variation and GWAS summary statistics to quantify recent transient directional selection acting on a complex trait. Through simulations of polygenic trait architecture evolution and GWASs, we show the method substantially improves power over current methods. We examine the robustness of the method under stratification, uncertainty and bias in marginal effects, uncertainty in the causal SNPs, allelic heterogeneity, negative selection, and low GWAS sample size. The method can quantify selection acting on correlated traits, controlling for pleiotropy even among traits with strong genetic correlation (|r
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