Evidence map›Paper›PMID 33440153›Full record

ArticleCell reports2021

Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen.

Luara Isabela Dos Santos, Thais Abdala Torres, Suelen Queiroz Diniz, Ricardo Gonçalves, Gustavo Caballero-Flores, Gabriel Núñez, Ricardo Tostes Gazzinelli, Kevin Joseph Maloy, Lis Ribeiro do V Antonelli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Luara Isabela Dos SantosInstituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte 30190-009, Minas Gerais, Brazil; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Thais Abdala TorresInstituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte 30190-009, Minas Gerais, Brazil; Instituto de Ciências Biológicas, Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil.
Suelen Queiroz DinizInstituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte 30190-009, Minas Gerais, Brazil; Instituto de Ciências Biológicas, Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil.
Ricardo GonçalvesDepartamento de Patologia Geral, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Minhas Gerais, Brazil.
Gustavo Caballero-FloresDepartment of Pathology and Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Gabriel NúñezDepartment of Pathology and Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Ricardo Tostes GazzinelliInstituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte 30190-009, Minas Gerais, Brazil; Instituto de Ciências Biológicas, Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil; University of Massachusetts Medical School, Worcester, MA 01605-2324, USA.
Kevin Joseph MaloySir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK; Institute of Infection, Immunity and Inflammation, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow G12 8TA, Scotland. Electronic address: kevin.maloy@glasgow.ac.uk.
Lis Ribeiro do V AntonelliInstituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte 30190-009, Minas Gerais, Brazil. Electronic address: lis.antonelli@fiocruz.br.
Universidade Federal de Minas Gerais · BRUniversity of Michigan · USUniversity of Oxford · GBFundação Oswaldo Cruz · BR

Funding

Role of Immunity and the Microbiota in Enteropathogenic E. coli EradicationR01DK095782 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NUNEZ, GABRIEL · 2013 to 2022
$3.6M
Monocyte-derived dendritic cells in malariaR01NS098747 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAZZINELLI, RICARDO TOSTES, LUSTER, ANDREW D · 2016 to 2020
$2.1M
Host Ciracadian Clock and MalariaR21AI150546 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAZZINELLI, RICARDO TOSTES · 2020 to 2021
$461k
NIAID NIH HHS R21 AI150546NIDDK NIH HHS R01 DK095782NINDS NIH HHS R01 NS098747Wellcome Trust
6 · The paper itself

Abstract

Individuals with malaria exhibit increased morbidity and mortality when infected with Gram-negative (Gr-) bacteria. To explore this experimentally, we performed co-infection of mice with Plasmodium chabaudi and Citrobacter rodentium, an extracellular Gr- bacterial pathogen that infects the large intestine. While single infections are controlled effectively, co-infection results in enhanced virulence that is characterized by prolonged systemic bacterial persistence and high mortality. Mortality in co-infected mice is associated with disrupted iron metabolism, elevated levels of plasma heme, and increased mitochondrial reactive oxygen species (ROS) production by phagocytes. In addition, iron acquisition by the bacterium plays a key role in pathogenesis because co-infection with a mutant C. rodentium strain lacking a critical iron acquisition pathway does not cause mortality. These results indicate that disrupted iron metabolism may drive mortality during co-infection with C. rodentium and P. chabaudi by both altering host immune responses and facilitating bacterial persistence.

Indexed as

AnimalsCoinfectionEnterobacteriaceae InfectionsHumansIntestinesIronMalariaMiceSurvival AnalysisIronCitrobacter rodentiumco-infectionGram-negative bacteriahemehemolysisironmalariamortalityPlasmodium

Identifiers

PMID33440153
PMCPMC8655499
OpenAlexW3118312558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.