ArticlePloS one2021
Utilization of the Naranjo scale to evaluate adverse drug reactions at a free-standing children's hospital.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
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- A Case of Ertapenem-Induced Neurotoxicity in an Elderly Patient With Reduced Renal Function.Cureus · 2025Article
- Serious Adverse Events: A Replicability and Validation Study of Naranjo Causality Assessment Tool in a Canadian Clinical Setting.Journal of evaluation in clinical practice · 2025Article
- Efficacy and safety of polymyxin B sulfate versus colistin sulfate in ICU patients with nosocomial pneumonia caused by carbapenem-resistant Acinetobacter baumannii: a multicenter, propensity score-matched, real-world cohort study.BMC infectious diseases · 2025Article
- Substandard antibiotics and their clinical outcomes among hospitalized patients in southern Malawi: a pilot study.Frontiers in pharmacology · 2025Article
- Medication Management Through Collaborative Practice for Children With Medical Complexity: A Prospective Case Series.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- Efficacy and safety of alpha-pinene capsule in the management of functional dyspepsia and eradication of helicobacter pylori: a randomized clinical trial.Gastroenterology and hepatology from bed to bench · 2024Article
- Hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction: a case report.European journal of hospital pharmacy : science and practice · 2023Article
- Causality assessment of adverse drug reactions in neonates: a comparative study between Naranjo's algorithm and Du's tool.International journal of clinical pharmacy · 2023Observational
- Evaluating the Safety and Efficacy of Naloxegol in Critically Ill Opioid-Induced Constipation Patients.Cureus · 2023Article
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- Anaphylaxis spares no drug: A report of diclofenac-induced anaphylaxis mimicking post-laparoscopy respiratory complication.Saudi journal of anaesthesiaArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between the Naranjo scaling system and pediatric adverse drug reactions (ADR) is poorly understood. We performed a retrospective review of 1,676 pediatric ADRs documented at our hospital from 2014-2018. We evaluated patient demographics, implicated medication, ADR severity, calculated Naranjo score, associated symptoms, and location within the hospital in which the ADR was documented. ADR severity was poorly correlated with Naranjo interpretation. Out of the 10 Naranjo scale questions, 4 had a response of "unknown" greater than 85% of the time. Cardiovascular and oncological/immunologic agents were more likely to have a probable or definite Naranjo interpretation compared to antimicrobials. Further strategies are needed to enhance the causality assessment of pediatric ADRs in clinical care.
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