ArticleAmerican journal of physiology. Cell physiology2021
The ocular pulse decreases aqueous humor outflow resistance by stimulating nitric oxide production.
Article in American journal of physiology. Cell physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Stretch strain shifts optic nerve head astrocyte metabolism to enrich α-ketoglutarate and the pentose phosphate pathway.Scientific reports · 2026Article
- The Factors Affecting the Stability of IOP Homeostasis.Investigative ophthalmology & visual science · 2024Article
- Trabecular Meshwork Movement Controls Distal Valves and Chambers: New Glaucoma Medical and Surgical Targets.Journal of clinical medicine · 2023Review
- A position- and time-dependent pressure profile to model viscoelastic mechanical behavior of the brain tissue due to tumor growth.Computer methods in biomechanics and biomedical engineering · 2023Article
- Ocular Biomechanics and Glaucoma.Vision (Basel, Switzerland) · 2023Review
- Modeling the Endothelial Glycocalyx Layer in the Human Conventional Aqueous Outflow Pathway.Cells · 2022Article
- The Effect of Intraocular Pressure Load Boundary on the Biomechanics of the Human Conventional Aqueous Outflow Pathway.Bioengineering (Basel, Switzerland) · 2022Article
- Measurement of postmortem outflow facility using iPerfusion.Experimental eye research · 2022Article
- Modeling the biomechanics of the conventional aqueous outflow pathway microstructure in the human eye.Computer methods and programs in biomedicine · 2022Article
- The role of microRNAs in glaucoma.Experimental eye research · 2022Review
- Extracellular matrix gene expression in human trabecular meshwork cells following mechanical fluid flow stimulation.International journal of ophthalmology · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Intraocular pressure (IOP) is not static, but rather oscillates by 2-3 mmHg because of cardiac pulsations in ocular blood volume known as the ocular pulse. The ocular pulse induces pulsatile shear stress in Schlemm's canal (SC). We hypothesize that the ocular pulse modulates outflow facility by stimulating shear-induced nitric oxide (NO) production by SC cells. We confirmed that living mice exhibit an ocular pulse with a peak-to-peak (pk-pk) amplitude of 0.5 mmHg under anesthesia. Using
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Registered trials
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