Evidence map›Paper›PMID 33439759›Full record

ArticleJournal of neurophysiology2021

Paired-pulse TMS and scalp EEG reveal systematic relationship between inhibitory GABA

Megan Hynd, Cheol Soh, Benjamin O Rangel, Jan R Wessel

Open access · greenAbstract read
In one paragraph

Article in Journal of neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Common and Unique Neurophysiological Processes That Support the Stopping and Revising of Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Does the stop-signal P3 reflect inhibitory control?Cortex; a journal devoted to the study of the nervous system and behavior · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Two Types of Motor Inhibition after Action Errors in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Megan HyndDepartment of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa.
Cheol SohDepartment of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa.
Benjamin O RangelInterdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, Iowa.ORCID 0000-0002-1893-2979
Jan R WesselDepartment of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa.
University of Iowa · US

Funding

The role of cortical and subcortical β-bursts in the cognitive control of human movementR01NS117753 · NINDS · UNIVERSITY OF IOWA · PI Jan R Wessel · 2020 to 2026
$2.9M
NINDS NIH HHS R01 NS117753
6 · The paper itself

Abstract

By stopping actions even after their initiation, humans can flexibly adapt ongoing behavior to changing circumstances. The neural processes underlying the inhibition of movement during action stopping are still controversial. In the 90s, a fronto-central event-related potential (ERP) was discovered in the human EEG response to stop signals in the classic stop-signal task, alongside a proposal that this "stop-signal P3" reflects an inhibitory process. Indeed, both amplitude and onset of the stop-signal P3 relate to overt behavior and movement-related EEG activity in ways predicted by the dominant models of action-stopping. However, neither EEG nor behavior allow direct inferences about the presence or absence of neurophysiological inhibition of the motor cortex, making it impossible to definitively relate the stop-signal P3 to inhibition. Here, we therefore present a multimethod investigation of the relationship between the stop-signal P3 and GABAergic signaling in primary motor cortex, as indexed by paired-pulse transcranial magnetic stimulation (TMS). In detail, we measured short-interval intracortical inhibition (SICI), a marker of inhibitory GABA

Indexed as

MovementNeural InhibitionAdolescentAdultElectroencephalographyEvoked PotentialsFemaleFrontal LobeGABAergic NeuronsHumansMaleMotor CortexReceptors, GABA-ATranscranial Magnetic StimulationReceptors, GABA-AGABAmotor inhibitionP3 event-related potentialpaired-pulse TMSstop-signal task

Identifiers

PMID33439759
PMCPMC7948136
OpenAlexW3120092909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.