Evidence map›Paper›PMID 33439538›Full record

ArticleJournal of biophotonics2021

In vivo dynamic characterization of the human tympanic membrane using pneumatic optical coherence tomography.

Jungeun Won, Ryan G Porter, Michael A Novak, Jon Youakim, Ada Sum, Ronit Barkalifa, Edita Aksamitiene, Anqi Zhang, Ryan Nolan, Ryan Shelton and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of biophotonics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Non-rigid point cloud registration for middle ear diagnostics with endoscopic optical coherence tomography.International journal of computer assisted radiology and surgery · 2024
    Article
  3. Journal of biomedical optics · 2023
    Article
  4. Differentiation of otitis media-causing bacteria and biofilmsFrontiers in cellular and infection microbiology · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jungeun WonDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0003-1007-4049
Ryan G PorterDepartment of Otolaryngology, Carle Foundation Hospital, Urbana, Illinois, USA.
Michael A NovakDepartment of Otolaryngology, Carle Foundation Hospital, Urbana, Illinois, USA.
Jon YouakimDepartment of Pediatrics, Carle Foundation Hospital, Urbana, Illinois, USA.
Ada SumDepartment of Pediatrics, Carle Foundation Hospital, Urbana, Illinois, USA.
Ronit BarkalifaBeckman Institute for Advanced Science and Technology, Urbana, Illinois, USA.
Edita AksamitieneBeckman Institute for Advanced Science and Technology, Urbana, Illinois, USA.
Anqi ZhangPhotoniCare, Inc., Champaign, Illinois, USA.
Ryan NolanPhotoniCare, Inc., Champaign, Illinois, USA.
Ryan SheltonPhotoniCare, Inc., Champaign, Illinois, USA.
Stephen A BoppartDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0002-9386-5630
Carle Foundation Hospital · USPhotoniCare (United States) · USUniversity of Illinois Urbana-Champaign · US

Funding

Partnership for Primary Care Imaging of the EarR01EB013723 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BOPPART, STEPHEN A · 2011 to 2018
$6.4M
Integration of Raman Spectroscopy and Optical Coherence Tomography (RS-OCT) for In-Vivo Identification of Bacterial Otitis MediaR01EB028615 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BOPPART, STEPHEN A, MAHADEVAN-JANSEN, ANITA · 2019 to 2022
$2.5M
NIBIB NIH HHS R01 EB013723NIBIB NIH HHS R01EB013723NIBIB NIH HHS R01 EB028615NIBIB NIH HHS R01EB028615
6 · The paper itself

Abstract

Decreased mobility of the human eardrum, the tympanic membrane (TM), is an essential indicator of a prevalent middle ear infection. The current diagnostic method to assess TM mobility is via pneumatic otoscopy, which provides subjective and qualitative information of subtle motion. In this study, a handheld spectral-domain pneumatic optical coherence tomography system was developed to simultaneously measure the displacement of the TM, air pressure inputs applied to a sealed ear canal, and to perform digital pneumatic otoscopy. A novel approach based on quantitative parameters is presented to characterize spatial and temporal variations of the dynamic TM motion. Furthermore, the TM motions of normal middle ears are compared with those of ears with middle ear infections. The capability of noninvasively measuring the rapid motion of the TM is beneficial to understand the complex dynamics of the human TM, and can ultimately lead to improved diagnosis and management of middle ear infections.

Indexed as

Otitis MediaTympanic MembraneEar, MiddleHumansMotionTomography, Optical Coherencebiomechanicsoptical coherence tomographyotitis mediatympanic membraneviscoelasticity

Identifiers

PMID33439538
PMCPMC7935452
OpenAlexW3045043232

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.