Evidence map›Paper›PMID 33439377›Full record

ArticleLasers in medical science2022

Antitumor effects of targeted killing of tumor-associated macrophages under photothermal conditions.

Bo Wang, Ying Huang

Abstract read
PubMed Publisher
In one paragraph

Article in Lasers in medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bo WangDepartment of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China.ORCID https://orcid.org/0000-0001-5807-6815
Ying HuangDepartment of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China. huangying712@163.com.ORCID http://orcid.org/0000-0002-3361-7184

Funding

Department of Education of Liaoning Province (CN) ZF2019023Key Research and Development Plan of Liaoning Province (CN) 2019JH8/10300008
6 · The paper itself

Abstract

Immunotherapy of tumors has become a research hotspot. Tumor-associated macrophages (TAMs) are the most abundant interstitial cells in a tumor's microenvironment. As the concentration of the prepared nanoparticles increased, so their cytotoxicity of intensified. Under photothermal conditions, mAb-CD163/Au inhibited tumor invasion by killing M2 macrophages in vitro. After exposure to near-infrared (NIR) laser, mAb-CD163/Au inhibited tumor growth in vivo. The gold nanoparticles were modified to target M2 macrophages. Under NIR laser irradiation, mAb-CD163/Au achieved antitumor effects by killing M2 macrophages in vitro and in vivo.

Indexed as

GoldMetal NanoparticlesHomicidePhototherapyTumor-Associated MacrophagesGoldCancer immunotherapyMonoclonal antibodyNanoparticlesPhotothermal therapyTumor-associated macrophages

Identifiers

PMID33439377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.