Evidence map›Paper›PMID 33439300›Full record

SynthesisArchives of gynecology and obstetrics2021

Association of metabolic and inflammatory markers with polycystic ovarian syndrome (PCOS): an update.

Subeka Abraham Gnanadass, Yogamaya Divakar Prabhu, Abilash Valsala Gopalakrishnan

3 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Archives of gynecology and obstetrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 142 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 7 pooled it
37.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05952349 phase2completednot on this mapstarted 2023, after this paper: background citation

Effect of Metformin and Combination of Olive Oil Plus Nutritional Supplements on Inflammatory Markers IL-6 and IL-8 in PCOS.

TypeinterventionalSponsorKhyber Medical University PeshawarRan2023 to 2024Enrolled88ConditionsPCOArmsOLIVE OIL 5ML/5MG (BD) NUTRITIONAL SACHET 2100MG (BD), Metformin (1000 mg Twice a day)
NCT06461585 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effects of Sprint Interval Training Versus Arabic Exercises BMI Waist-to-hip Ratio and Quality of Life in Obese Women PCOS

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2024Enrolled36ConditionsPCOSArmsSprint interval training
NCT06567132 nacompletednot on this mapstarted 2022, after this paper: background citation

Evaluation of the Effect of Non-Surgical Periodontal Treatment on IL-6, IL-10 and ANXA-1 Levels in Women With Polycystic Ovary Syndrome

TypeinterventionalSponsorBezmialem Vakif UniversityRan2022 to 2023Enrolled80ConditionsPolycystic Ovary Syndrome, GingivitisArmsNon-surgical periodontal treatment
3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 7 syntheses or guidelines pooled it, 260 citations in OpenAlex.

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82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Subeka Abraham GnanadassDepartment of Biomedical Sciences, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India.
Yogamaya Divakar PrabhuDepartment of Biomedical Sciences, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India.
Abilash Valsala GopalakrishnanDepartment of Biomedical Sciences, School of BioSciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India. abilash.vg@vit.ac.in.ORCID http://orcid.org/0000-0003-0780-0492
Vellore Institute of Technology University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolycystic ovarian syndrome (PCOS) is the most prevalent metabolic disorder in reproductive-age women. It is indeed a multifactorial condition evidenced by ovarian dysfunction, hyperandrogenaemia, infertility, hormonal imbalance and chronic anovulation. Experimental evidence infers that PCOS women are prone to cardiovascular problems and insulin resistance. PURPOSE: To furnish the details about the association of inflammatory markers in PCOS.

designAn extensive literature search on PubMed, science direct and google scholar has been performed for articles about PCOS and inflammation in PCOS. A comprehensive analysis using original articles, reviews, systemic and meta-analysis was conducted for better understanding the relationship between inflammatory cytokines and PCOS.

resultsThe inflammatory markers perform a substantial part in managing the functions of the ovary. Any disturbances in their levels can lead to ovarian dysfunction. Inflammatory markers are associated with PCOS pathogenesis. The interplay between inflammatory cytokines in the PCOS ovary strongly implies that inflammation is one of the most potent risk factors of PCOS.

conclusionInflammatory markers have a significant role in regulating the ovary. This manuscript highlights the significance of metabolic and inflammatory markers with PCOS. Since PCOS is always considered as a metabolic disorder, researchers can also consider focusing on the relationship between the inflammatory markers in PCOS to establish a new treatment or management of the disease and to improve women's health.

Indexed as

AnovulationBiomarkersCytokinesFemaleHumansHyperandrogenismInfertilityInflammationInsulinInsulin ResistanceInterleukin-6Metabolic SyndromePolycystic Ovary SyndromeTumor Necrosis Factor-alphaBiomarkersCytokinesInsulinInterleukin-6Tumor Necrosis Factor-alphaCRPCytokinesIL-6InflammationPCOSTNF-α

Identifiers

PMID33439300
OpenAlexW3118505053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.