ArticleEnvironmental health perspectives2021
Filaggrin Polymorphisms and the Uptake of Chemicals through the Skin-A Human Experimental Study.
Article in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Polymorphisms in CLAUDIN1 and SPINK5 Influence Skin Absorption of Pyrene, Pyrimethanil, and Oxybenzone in Human Volunteers.Environmental and molecular mutagenesis · 2026Article
- Review
- Determination of pesticide residues in urine by chromatography-mass spectrometry: methods and applications.Frontiers in public health · 2024Review
- Exposure to the anti-microbial chemical triclosan disrupts keratinocyte function and skin integrity in a model of reconstructed human epidermis.Journal of immunotoxicology · 2023Article
- Bioinspired polydopamine nanoparticles as efficient antioxidative and anti-inflammatory enhancers against UV-induced skin damage.Journal of nanobiotechnology · 2023Article
- Nickel penetration into stratum corneum in FLG null carriers-A human experimental study.Contact dermatitis · 2022Article
- Underground emissions and miners' personal exposure to diesel and renewable diesel exhaust in a Swedish iron ore mine.International archives of occupational and environmental health · 2022Article
- NiFrontiers in molecular biosciences · 2022Article
- Dermal Exposure to the Immunomodulatory Antimicrobial Chemical Triclosan Alters the Skin Barrier Integrity and Microbiome in Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Uptake of Chemicals through the Skin: An Important Role of Filaggrin Gene Variants.Environmental health perspectives · 2021Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe filaggrin protein is important for skin barrier structure and function. Loss-of-function (null) mutations in the filaggrin gene
objectiveThe objective of the study was to clarify if dermal absorption of chemicals differs depending on
methodWe performed a quantitative real-time polymerase chain reaction (qPCR)-based genetic screen for loss-of-function mutations (
resultsLag times for the uptake and dermal absorption rate of the chemicals differed significantly between
conclusionWe conclude that
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.