ArticleMicrobial biotechnology2021
Yarrowia lipolytica chassis strains engineered to produce aromatic amino acids via the shikimate pathway.
Article in Microbial biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- High-yield production of hydroxytyrosol through metabolic engineering ofSynthetic and systems biotechnology · 2026Article
- Combining multiplex metabolic engineering with adaptive evolution strategies for high-level succinic acid production inSynthetic and systems biotechnology · 2026Article
- Engineering yeast for sustainable bioproduction of tryptophan-derived aromatic compounds.FEMS yeast research · 2026Review
- In vitro anticancer activity of prodeoxyviolacein produced by3 Biotech · 2025Article
- Advances in synthesizing plant-derived isoflavones and their precursors with multiple pharmacological activities using engineered yeasts.Microbial cell factories · 2025Review
- Computational biology predicts metabolic engineering targets for increased production of 103 valuable chemicals in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Comprehensive investigations of 2-phenylethanol production by the filamentous fungus Annulohypoxylon stygium.Applied microbiology and biotechnology · 2024Article
- The outlooks and key challenges in renewable biomass feedstock utilization for value-added platform chemical via bioprocesses.Heliyon · 2024Review
- Aromatic secondary metabolite production from glycerol was enhanced by amino acid addition in Pichia pastoris.Applied microbiology and biotechnology · 2023Article
- Beet red food colourant can be produced more sustainably with engineered Yarrowia lipolytica.Nature microbiology · 2023Article
- Mechanistic investigation of a D to N mutation in DAHP synthase that dictates carbon flux into the shikimate pathway in yeast.Communications chemistry · 2023Article
- Metabolic profiles and fingerprints for the investigation of the influence of nitisinone on the metabolism of the yeast Saccharomyces cerevisiae.Scientific reports · 2023Article
- Article
- New insights and advances on pyomelanin production: from microbial synthesis to applications.Journal of industrial microbiology & biotechnology · 2022Review
- Engineering ergothioneine production in Yarrowia lipolytica.FEBS letters · 2022Article
- Bioproduction of 2-Phenylethanol through Yeast Fermentation on Synthetic Media and on Agro-Industrial Waste and By-Products: A Review.Foods (Basel, Switzerland) · 2022Review
- Yarrowia lipolytica chassis strains engineered to produce aromatic amino acids via the shikimate pathway.Microbial biotechnology · 2021Article
- Advances in engineering microbial biosynthesis of aromatic compounds and related compounds.Bioresources and bioprocessing · 2021Review
- AMicroorganisms · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yarrowia lipolytica is widely used as a microbial producer of lipids and lipid derivatives. Here, we exploited this yeast's potential to generate aromatic amino acids by developing chassis strains optimized for the production of phenylalanine, tyrosine and tryptophan. We engineered the shikimate pathway to overexpress a combination of Y. lipolytica and heterologous feedback-insensitive enzyme variants. Our best chassis strain displayed high levels of de novo Ehrlich metabolite production (up to 0.14 g l
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