Evidence map›Paper›PMID 33438789›Full record

ArticleStem cells (Dayton, Ohio)2021

Telomerase expression marks transitional growth-associated skeletal progenitor/stem cells.

Diana L Carlone, Rebecca D Riba-Wolman, Luke T Deary, Alessio Tovaglieri, Lijie Jiang, Dana M Ambruzs, Benjamin E Mead, Manasvi S Shah, Christopher J Lengner, Rudolf Jaenisch and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Stem cells (Dayton, Ohio), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. New perspective of skeletal stem cells.Biomaterials translational · 2022
    Review
  6. Regulation and Role of Transcription Factors in Osteogenesis.International journal of molecular sciences · 2021
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Diana L CarloneDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-6935-0189
Rebecca D Riba-WolmanDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.
Luke T DearyDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.
Alessio TovaglieriDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.
Lijie JiangDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.
Dana M AmbruzsDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.
Benjamin E MeadDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.
Manasvi S ShahDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.
Christopher J LengnerDepartment of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Rudolf JaenischWhitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.
David T BreaultDivision of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.
Boston Children's Hospital · USUniversity of Pennsylvania · USWhitehead Institute for Biomedical Research · US

Funding

SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
The role of mTert-expressing stem cells in tooth formation and renewalR21DE022420 · NIDCR · BOSTON CHILDREN'S HOSPITAL · PI CARLONE, DIANA LYNN · 2012 to 2013
$470k
Transitional Growth-Associated Skeletal Stem CellsR03AG054723 · NIA · BOSTON CHILDREN'S HOSPITAL · PI CARLONE, DIANA LYNN · 2017 to 2018
$354k
NIA NIH HHS R03 AG054723NICHD NIH HHS P30 HD018655NIDCR NIH HHS R21 DE022420
6 · The paper itself

Abstract

Skeletal progenitor/stem cells (SSCs) play a critical role in postnatal bone growth and maintenance. Telomerase (Tert) activity prevents cellular senescence and is required for maintenance of stem cells in self-renewing tissues. Here we investigated the role of mTert-expressing cells in postnatal mouse long bone and found that mTert expression is enriched at the time of adolescent bone growth. mTert-GFP

Indexed as

AnimalsBone MarrowCell CycleCell ProliferationCellular SenescenceEpithelial CellsMiceStem CellsTelomeraseTelomerasemTertpluripotentpostnatal bone growthskeletal stem cellstelomerase

Identifiers

PMID33438789
PMCPMC7986156
OpenAlexW3118691148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.