Evidence map›Paper›PMID 33438668›Full record

ArticleBiomedical physics & engineering express2020

SimBSI: An open-source Simulink library for developing closed-loop brain signal interfaces in animals and humans.

Alejandro Ojeda, Nathalie Buscher, Pragathi Balasubramani, Vojislav Maric, Dhakshin Ramanathan, Jyoti Mishra

Abstract read
In one paragraph

Article in Biomedical physics & engineering express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alejandro OjedaNeural Engineering and Translation Labs, Department of Psychiatry, University of California San Diego, La Jolla , California, United States of America.ORCID 0000-0002-7878-0129
Nathalie BuscherNeural Engineering and Translation Labs, Department of Psychiatry, University of California San Diego, La Jolla , California, United States of America.
Pragathi BalasubramaniNeural Engineering and Translation Labs, Department of Psychiatry, University of California San Diego, La Jolla , California, United States of America.
Vojislav MaricNeural Engineering and Translation Labs, Department of Psychiatry, University of California San Diego, La Jolla , California, United States of America.
Dhakshin RamanathanNeural Engineering and Translation Labs, Department of Psychiatry, University of California San Diego, La Jolla , California, United States of America.
Jyoti MishraNeural Engineering and Translation Labs, Department of Psychiatry, University of California San Diego, La Jolla , California, United States of America.

Funding

Fellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3M
TRAINING PROGRAM IN COGNITIVE NEUROSCIENCET32MH020002 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SEJNOWSKI, TERRENCE J · 1999 to 2020
$6.1M
Identifying and Targeting Physiological Assays of Circuit Engagement to Improve ImpulsivityR01MH123650 · NIMH · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI MISHRA, JYOTI, RAMANATHAN, DHAKSHIN · 2021 to 2025
$1.8M
Enhancing Neural Circuit Plasticity to Promote Recovery After TBIIK2BX003308 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI RAMANATHAN, DHAKSHIN · 2016 to 2020
–
BLRD VA IK2 BX003308NIMH NIH HHS R01 MH123650NIMH NIH HHS T32 MH018399NIMH NIH HHS T32 MH020002
6 · The paper itself

Abstract

objectiveA promising application of BCI technology is in the development of personalized therapies that can target neural circuits linked to mental or physical disabilities. Typical BCIs, however, offer limited value due to simplistic designs and poor understanding of the conditions being treated. Building BCIs on more solid grounds may require the characterization of the brain dynamics supporting cognition and behavior at multiple scales, from single-cell and local field potential (LFP) recordings in animals to non-invasive electroencephalography (EEG) in humans. Despite recent efforts, a unifying software framework to support closed-loop studies in both animals and humans is still lacking. The objective of this paper is to develop such a unifying neurotechnological software framework. APPROACH: Here we develop the Simulink for Brain Signal Interfaces library (SimBSI). Simulink is a mature graphical programming environment within MATLAB that has gained traction for processing electrophysiological data. SimBSI adds to this ecosystem: 1) advanced human EEG source imaging, 2) cross-species multimodal data acquisition based on the Lab Streaming Layer library, and 3) a graphical experimental design platform. MAIN

resultsWe use several examples to demonstrate the capabilities of the library, ranging from simple signal processing, to online EEG source imaging, cognitive task design, and closed-loop neuromodulation. We further demonstrate the simplicity of developing a sophisticated experimental environment for rodents within this environment. SIGNIFICANCE: With the SimBSI library we hope to aid BCI practitioners of dissimilar backgrounds in the development of, much needed, single and cross-species closed-loop neuroscientific experiments. These experiments may provide the necessary mechanistic data for BCIs to become effective therapeutic tools.

Indexed as

Brain-Computer InterfacesSignal Processing, Computer-AssistedSoftwareAlgorithmsAnimalsBehavior, AnimalBrainComputer GraphicsComputersElectroencephalographyHumansMiceProgramming LanguagesSpecies SpecificityUser-Computer Interface

Identifiers

PMID33438668
PMCPMC10092292

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.