Evidence map›Paper›PMID 33438263›Full record

ArticleJournal of leukocyte biology2021

Frontline Science: The expression of integrin α

William P Bailey, Kui Cui, Christopher L Ardell, Kasey R Keever, Sanjay Singh, Diego J Rodriguez-Gil, Tammy R Ozment, David L Williams, Valentin P Yakubenko

Open access · greenAbstract read
In one paragraph

Article in Journal of leukocyte biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Platelets in Alcohol-Associated Liver Disease: Interaction With Neutrophils.Cellular and molecular gastroenterology and hepatology · 2024
    Review
  7. Review
  8. CCN1/Integrin αNutrients · 2022
    Article
  9. Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

William P BaileyDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Kui CuiDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Christopher L ArdellDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Kasey R KeeverDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Sanjay SinghDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Diego J Rodriguez-GilDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Tammy R OzmentDepartment of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
David L WilliamsDepartment of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Valentin P YakubenkoDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
East Tennessee State University · US

Funding

Training Innate Immunity: A new approach to the treatment of SepsisR01GM119197 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI SHERWOOD, EDWARD R, WILLIAMS, DAVID L. · 2016 to 2024
$4.6M
Innate Immunity and Cardiovascular Function in SepsisR01GM083016 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI LI, CHUANFU, WILLIAMS, DAVID L. · 2009 to 2021
$3.8M
Equipment Supplement Requisition for Mesoscale Quick Plex SQ 120mm ReaderR01GM122934 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI OZMENT, TAMMY REGENA · 2017 to 2021
$1.5M
The role of β2 integrins in macrophage retention and egress during inflammationR01DK102020 · NIDDK · EAST TENNESSEE STATE UNIVERSITY · PI YAKUBENKO, VALENTIN P · 2014 to 2017
$1.2M
NIDDK NIH HHS R01 DK102020NIGMS NIH HHS R01 GM083016NIGMS NIH HHS R01 GM119197NIGMS NIH HHS R01 GM122934NIH HHS C06RR0306551NIH HHS R01DK102020NIH HHS RO1GM083016NIH HHS RO1GM119197NIH HHS RO1GM122934Tennessee State University
6 · The paper itself

Abstract

Neutrophil-macrophage interplay is a fine-tuning mechanism that regulates the innate immune response during infection and inflammation. Cell surface receptors play an essential role in neutrophil and macrophage functions. The same receptor can provide different outcomes within diverse leukocyte subsets in different inflammatory conditions. Understanding the variety of responses mediated by one receptor is critical for the development of anti-inflammatory treatments. In this study, we evaluated the role of a leukocyte adhesive receptor, integrin α

Indexed as

Adoptive TransferAnimalsCecumCell CountCell MovementCytokinesDisease Models, AnimalEndotoxemiaIntegrin alpha ChainsLigationLipopolysaccharidesLungMacrophagesMaleMiceMice, Inbred C57BLCytokinesIntegrin alpha ChainsItgad protein, mouseLipopolysaccharidesCD11d/CD18endotoxemiainflammationintegrin αDβ2macrophagesneutrophilssepsis

Identifiers

PMID33438263
PMCPMC8085079
OpenAlexW3118980730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.