Evidence map›Paper›PMID 33437870›Full record

ArticleAJSP: reviews & reports

Transformation of monoclonal B lymphocytosis to Epstein-Barr virus-positive large B-cell lymphoma with intermediate features between diffuse large B-cell lymphoma and classic Hodgkin lymphoma.

Ying Liu, Caleb Ho, Mikhail Roshal, Jeeyeon Baik, Maria Arcila, Yanming Zhang, Ahmet Dogan, Wenbin Xiao

Open access · greenAbstract read
In one paragraph

Article in AJSP: reviews & reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 69% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ying LiuDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Caleb HoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Mikhail RoshalDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Jeeyeon BaikDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Maria ArcilaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Yanming ZhangDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Ahmet DoganDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Wenbin XiaoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Transformation of chronic lymphocytic leukemia (CLL) to an aggressive lymphoma, so-called Richter syndrome (RS), usually includes diffuse large B-cell lymphoma (DLBCL) and classic Hodgkin lymphoma (CHL). The transformation can be clonally related to the underlying CLL, and is often Epstein-Barr virus (EBV)-associated. Here we report an 86-year-old female with a newly identified CLL-like monoclonal B-lymphocytosis (MBL) who developed diffuse lymphadenopathy. Biopsy of the left axillary lymph node showed EBV-positive large B-cell lymphoma with morphologic and immunophenotypic features intermediate between DLBCL and CHL, so-called gray zone lymphoma. Comprehensive immunophenotypic, cytogenetics and molecular studies demonstrate a clonal relatedness that suggests a transformation from MBL to EBV+ gray zone lymphoma.

Indexed as

Chronic lymphocytic leukemiaclassic Hodgkin lymphomaEBV+ diffuse large B-cell lymphomagray zone lymphomamonoclonal B-lymphocytosisRichter syndrome/transformation

Identifiers

PMID33437870
PMCPMC7799843
OpenAlexW3118930132

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.