Evidence map›Paper›PMID 33437832›Full record

ArticlemHealth2020

A pilot randomized controlled trial (RCT) of daily versus weekly interactive voice response calls to support adherence among antiretroviral treatment patients in India.

Dallas Swendeman, Anne E Fehrenbacher, Soma Roy, Protim Ray, Stephanie Sumstine, Aaron Scheffler, Rishi Das, Smaraijt Jana

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mHealth, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02118454 (ART Adherence Behaviour and Practices Among HIV Positives in Kolkata, India-a Pilot Project), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02118454 nacompletednot on this map

ART Adherence Behaviour and Practices Among HIV Positives in Kolkata, India-a Pilot Project

TypeinterventionalSponsorUniversity of California, Los AngelesRan2014 to 2015Enrolled400ConditionsHIV/AIDSArmsDaily IVR Calls Intervention, Weekly IVR Survey Only
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Dallas SwendemanDepartment of Psychiatry & Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, CA, USA.
Anne E FehrenbacherDepartment of Psychiatry & Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, CA, USA.
Soma RoySonagachi Research & Training Institute, Durbar Mahila Samanwaya Committee, 12/5 Nilmoni Mitra Street, Kolkata, West Bengal, India.
Protim RaySonagachi Research & Training Institute, Durbar Mahila Samanwaya Committee, 12/5 Nilmoni Mitra Street, Kolkata, West Bengal, India.
Stephanie SumstineDepartment of Psychiatry & Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, CA, USA.
Aaron SchefflerDepartment of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA.
Rishi DasDepartment of Psychiatry & Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, CA, USA.
Smaraijt JanaSonagachi Research & Training Institute, Durbar Mahila Samanwaya Committee, 12/5 Nilmoni Mitra Street, Kolkata, West Bengal, India.
University of California, Los Angeles · USDurbar Mahila Samanwaya Committee · INUniversity of California, San Francisco · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sung-Jae Lee · 1997 to 2026
$53.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZACK, JEROME A. · 1991 to 2018
$39.9M
Optimizing the HIV Treatment Continuum with a Stepped Care Model for Youth Living with HIVU19HD089886 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FERNANDEZ, MARIA ISABEL, ROTHERAM-BORUS, MARY JANE · 2016 to 2022
$23.4M
University of California Launching Future Leaders in Global Health Research Training ProgramD43TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIG R COHEN, Sung-Jae Lee · 2017 to 2026
$14.7M
Post-doctoral HIV Research Training Program for HIV Combination PreventionT32MH109205 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROTHERAM-BORUS, MARY JANE · 2016 to 2020
$2.3M
Mobile Phone Adherence & Prevention Support for People Living with HIV in IndiaR21AI094666 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SWENDEMAN, DALLAS TRAVIS · 2012 to 2013
$367k
FIC NIH HHS D43 TW009343NCATS NIH HHS UL1 TR000124NIAID NIH HHS P30 AI028697NIAID NIH HHS R21 AI094666NICHD NIH HHS U19 HD089886NIMH NIH HHS P30 MH058107NIMH NIH HHS T32 MH109205
6 · The paper itself

Abstract

backgroundThere are more than two million people living with HIV (PLH) in India, with more than 30% on antiretroviral treatment (ART) estimated to be non-adherent. This study aimed to (I) document adherence rates and related factors among ART patients in a large ART clinic in India, and (II) pilot test daily and weekly interactive voice response (IVR) calls to improve ART adherence and related outcomes.

methodsART patients reporting missing at least one dose in prior 6 months (N=362) were enrolled and assessed via self-report and medical record review. Participants were randomized to one of two conditions: (I) twice-daily IVR call reminders with self-management support messaging, plus a weekly IVR adherence assessment; or (II) an attention control, with only weekly IVR adherence assessment. Participants completed study assessments at baseline, 2-, 4-, and 6-months with high retention (88% to 96%).

resultsIntention-to-treat analyses found limited support for intervention effects for improving or maintaining ART adherence or CD4 counts between the two study arms over 6-months follow-up. Adherence increased significantly in the six months prior to baseline from about 65% to >95% with perfect adherence based on pill counts from medical records and consistent with patient self-report measures, which presented ceiling effects for detecting improvements in ART adherence in response to IVR intervention exposure. There was also limited support for intervention effects on secondary, self-management outcomes.

conclusionsHigh levels of adherence were sustained throughout the 6-month RCT. IVR regulation changes in India delayed study launch for 6 months, which likely allowed mobilization of improved adherence at the clinic, provider and patient levels in anticipation of the study launch. Therefore, ceiling effects limited inferences on intervention effects to improve adherence. Results suggest that clinic-level adherence monitoring may be sufficient to mobilize adherence improvements by providers and patients.

trial registrationClinicalTrials.gov registration #NCT02118454.

Indexed as

antiretroviral therapy adherenceHIVIndiainteractive voice responsemhealth

Identifiers

PMID33437832
PMCPMC7793015
OpenAlexW3042290512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.