ArticleAnnals of translational medicine2020
Design of the Shunyi study on cardiovascular disease and age-related brain changes: a community-based, prospective, cohort study.
Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Longitudinal Patterns of Brain Parenchymal Damage Associated With the ALPS Index in a Community-Based Cohort.CNS neuroscience & therapeutics · 2026Article
- Characteristics of brain structural damage related to cerebral small vessel disease in general population with intracranial artery stenosis.Stroke and vascular neurology · 2026Article
- HLA Class I Haplotype in Glutamic Acid Decarboxylase Antibody-Associated Neurological Disease.European journal of neurology · 2026Article
- Article
- Intracranial atherosclerosis increases risk of incident dementia in middle-aged general population.Chinese medical journal · 2026Article
- HLA genotyping and clinical characteristics of early-onset and late-onset anti-LGI1 encephalitis: a single-center cohort study in China.Frontiers in immunology · 2026Article
- Association of Serum Neurofilament Light and Glial Fibrillary Acidic Protein with Cerebral Small Vessel Disease in Nondemented Middle-to-Old Aged Population.Translational stroke research · 2025Article
- Closing the gap in dementia research by community-based cohort studies in the Chinese population.The Lancet regional health. Western Pacific · 2025Review
- Risk factor differences in five-year progression of Intracranial artery stenosis and cerebral small vessel disease in general population.BMC neurology · 2024Article
- Automated diffusion-weighted image analysis along the perivascular space index reveals glymphatic dysfunction in association with brain parenchymal lesions.Human brain mapping · 2024Article
- The genetic risk factors for cerebral venous thrombosis: a case-control study in a Chinese national comprehensive hospital.Thrombosis journal · 2024Article
- Dynamic Mechanism of Cerebral Venous Disruption: Longitudinal Evidence From a Community-Based Cohort.Journal of the American Heart Association · 2024Article
- Association of RareJournal of the American Heart Association · 2024Article
- Pattern of Brain Parenchymal Damage Related to Cerebral Small Vessel Disease in Carriers of RareNeurology · 2023Article
- Association between Anatomical Variations of the Circle of Willis and Covert Vascular Brain Injury in the General Population.Cerebrovascular diseases (Basel, Switzerland) · 2023Article
- White matter and gray matter changes related to cognition in community populations.Frontiers in aging neuroscience · 2023Article
- Deep medullary veins are associated with widespread brain structural abnormalities.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRapid economic growth and increasing lifespan have contributed to an increasing burden of chronic non-communicable diseases in China. Population-based studies focusing on cardiovascular disease and age-related brain changes, with extensive clinical, genetic, and imaging data as well as a comprehensive evaluation of brain function are lacking in China. The Shunyi cohort study aimed to investigate the determinants and consequences of cardiovascular disease and age-related brain alterations among individuals residing in a rural area of Beijing.
methodsThis prospective, community-based study included individuals aged 35 years and older living in five villages in Shunyi, a rural district located 20 miles from urban Beijing. A total of 1,586 individuals were enrolled between June 2013 and September 2014. Biological samples and brain magnetic resonance images were collected along with baseline clinical data through face-to-face interviews. Whole exome sequencing and quantitative assessments of cognitive and motor function were performed.
resultsAmong the 1,586 participants included, 40% were men, and the mean age of the cohort was 56.7±10.0 years. This population had a relatively low education level. A heavy burden of vascular risk factors with a low control rate was observed in the Shunyi population. Since 2017, the cohort has been followed up annually. As of October 2019, we had failed to obtain the follow-up data of five participants.
conclusionsWith an extensive range of clinical, genetic, and imaging data, the Shunyi cohort study has the potential to contribute significantly towards identifying the causes and consequences of cardiovascular disease and age-related brain changes in older people in China.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.