Evidence map›Paper›PMID 33437763›Full record

ArticleAnnals of translational medicine2020

Sensitivity and specificity of combination of Hull airway reflux questionnaire and gastroesophageal reflux disease questionnaire in identifying patients with gastroesophageal reflux-induced chronic cough.

Siwan Wen, Shengyuan Wang, Shanshan Niu, Mengru Zhang, Cuiqin Shi, Zhongmin Qiu, Xianghuai Xu, Li Yu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Evaluation methods and influencing factors of cough sensitivity.Therapeutic advances in respiratory disease
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Siwan WenDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji University, School of Medicine, Shanghai, China.
Shengyuan WangDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji University, School of Medicine, Shanghai, China.
Shanshan NiuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji University, School of Medicine, Shanghai, China.
Mengru ZhangDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji University, School of Medicine, Shanghai, China.
Cuiqin ShiDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji University, School of Medicine, Shanghai, China.
Zhongmin QiuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji University, School of Medicine, Shanghai, China.
Xianghuai XuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji University, School of Medicine, Shanghai, China.
Li YuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji University, School of Medicine, Shanghai, China.
Tongji University · CNTongji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a need to find a simple, non-invasive and effective diagnostic tool for diagnosing gastroesophageal reflux-induced chronic cough (GERC) in clinic. This study aimed to evaluate the predictive diagnostic value of Hull airway reflux questionnaire (HARQ) and its combination with gastroesophageal reflux disease questionnaire (GerdQ) for GERC.

methodsChronic cough patients were enrolled and the diagnosis of GERC was established according to the chronic cough diagnosis and treatment process. The diagnostic value of HARQ and GerdQ alone or the combination of HARQ and GerdQ was analyzed.

resultsA total of 402 patients with chronic cough were eventually enrolled, including 166 GERC patients. When the HARQ score was used to predict the diagnosis of GERC, the area under the ROC curve was 0.796. The sensitivity and specificity were 77.19% and 77.06%, respectively. When the GerdQ was used to predict the diagnosis of GERC, the area under the ROC curve was 0.763. The sensitivity and specificity were 70.18% and 76.15%, respectively. When HARQ combined with GerdQ were used to predict the diagnosis of GERC, the area under the ROC curve was 0.848. The sensitivity and specificity were 77.19% and 79.82%, respectively.

conclusionsHARQ used to evaluate the cough hypersensitivity has a certain predictive diagnostic value for GERC. The diagnosis of GERC should be considered when the HARQ score is ≥24. The predictive diagnostic value of the combination of HARQ and GerdQ is significantly higher, which makes the diagnosis of GERC simpler, quicker and more effective.

Indexed as

gastroesophageal reflux disease questionnaire (GerdQ)gastroesophageal reflux-induced chronic cough (GERC)Hull airway reflux questionnaire (HARQ)predictive diagnosis

Identifiers

PMID33437763
PMCPMC7791241
OpenAlexW3104340424

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.