ArticleAnnals of translational medicine2020
Cross-sectional analysis of the association between serum uric acid levels and handgrip strength among Chinese adults over 45 years of age.
Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Association of serum uric acid with cardiovascular-kidney-metabolic syndrome in elderly populations: results from Chinese and US cohorts.Scientific reports · 2026Article
- Inverted U-Shaped Association Between Serum Uric Acid and Handgrip Strength in Chinese Community-Dwelling Adults: A Repeated-Measures Cohort Study.Biomedicines · 2026Article
- Association of Serum Uric Acid With Relative Muscle Loss: A US Population-Based Cross-Sectional Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Skeletal muscle mass and quality in gout patients versus non-gout controls: A computed tomography imaging study.Joint bone spine · 2024Article
- L-shaped association between lean body mass to visceral fat mass ratio with hyperuricemia: a cross-sectional study.Lipids in health and disease · 2024Article
- The correlations of serum uric acid with lean mass, fat mass and grip strength in adolescents aged 12-19 years.Frontiers in endocrinology · 2024Article
- Association between elevated serum uric acid levels and high estimated glomerular filtration rate with reduced risk of low muscle strength in older people: a retrospective cohort study.BMC geriatrics · 2023Article
- Higher uric acid serum levels are associated with sarcopenia in west China: a cross-sectional study.BMC geriatrics · 2022Article
- Muscle Fat Content Is Strongly Associated With Hyperuricemia: A Cross-Sectional Study in Chinese Adults.Frontiers in endocrinology · 2022Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSarcopenia is the decline in muscle strength and mass attributed to aging. The pathogenesis of sarcopenia may be triggered by oxidative stress; uric acid (UA) has strong antioxidant properties. This study aimed to examine if the serum UA level is associated with handgrip strength (HGS), which is a useful indicator of sarcopenia among Chinese participants aged over 45.
methodsOur study included 992 eligible participants (583 males and 409 females). Based on serum UA quartiles and gender, the participants were divided into 8 groups. HGS was measured in kilograms using an electronic dynamometer. Face-to-face visits and fasting blood analyses were performed to determine the serum UA levels and various covariates. Univariate analysis of variance (ANOVA) and covariance (ANCOVA) was conducted to analyze the linear or quadratic trend between the UA levels and grip strength.
resultsParticipants were grouped according to UA quartiles by gender. In both genders, ANOVA showed an inverted J-shaped association between serum UA levels and HGS (P for quadratic trend =0.004 in men, P for quadratic trend =0.003 in women). After adjusting for potential confounders, the association between the UA quartiles and HGS was unchanged, irrespective of gender.
conclusionsThe results suggest that a specific range of serum UA levels may be associated with better HGS among Chinese adults aged over 45.
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