ArticleJournal of orthopaedic translation2021
An animal model of early-stage femoral head osteonecrosis induced by cryo-insult in small tailed Han sheep.
Article in Journal of orthopaedic translation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- An in-depth examination of bone avascular necrosis and early-stage treatment modalities utilizing regenerative medicine.Iranian journal of basic medical sciences · 2026Review
- Analysis of Animal Models of Traumatic Osteonecrosis of the Femoral Head Based on Blood Supply: A Literature Review.Orthopaedic surgery · 2025Review
- Article
- Advances in experimental models of osteonecrosis of the femoral head.Journal of orthopaedic translation · 2023Review
- A novel device for treatment of osteonecrosis of femoral head: Feasibility and preliminary efficacy of animal study.Journal of orthopaedic translation · 2021Article
- Medicine and models of degenerative orthopaedic disorders.Journal of orthopaedic translation · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study investigated the ability of liquid nitrogen cryo-insults to induce early-stage osteonecrosis of the femoral head (ONFH) in small tail Han sheep.
methods16 animals were subjected to unilateral cryo-insult using cryogen equipment with a cryo-insult probe, followed 1, 3, and 6 months later by X-ray, CT scanning, micro-CT scanning, and histological evaluation.
resultsX-ray evaluation of operative femoral heads (Op-FHs) at each time point showed low density areas under the cartilage surface that paralleled sclerosis belts, and CT scans showed sclerosis and cyst areas in Op-FHs. Micro-CT analysis showed that the ratio of bone to total volume and mean trabecular thickness of regions of interest (ROIs) were lower in Op-FHs than in normal femoral heads (No-FHs) at each time point (n = 4,
conclusionThese findings indicate that early-stage ONFH can be induced in small tail Han sheep using cryogenic equipment. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: This animal model may be helpful in developing new treatment modalities for human ONFH.
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Registered trials
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