Evidence map›Paper›PMID 33437567›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020

Magnetically Active Cardiac Patches as an Untethered, Non-Blood Contacting Ventricular Assist Device.

Hongri Gu, Thibaud Bertrand, Quentin Boehler, Christophe Chautems, Nikolay V Vasilyev, Bradley J Nelson

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Recent Progress in Active Mechanical Metamaterials and Construction Principles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Hongri GuInstitute of Robotics and Intelligent Systems ETH Zurich Zurich CH-8092 Switzerland.ORCID https://orcid.org/0000-0002-6396-3408
Thibaud BertrandInstitute of Robotics and Intelligent Systems ETH Zurich Zurich CH-8092 Switzerland.
Quentin BoehlerInstitute of Robotics and Intelligent Systems ETH Zurich Zurich CH-8092 Switzerland.ORCID https://orcid.org/0000-0001-7573-3135
Christophe ChautemsInstitute of Robotics and Intelligent Systems ETH Zurich Zurich CH-8092 Switzerland.
Nikolay V VasilyevDepartment of Cardiac Surgery Boston Children's Hospital Harvard Medical School Boston MA 02115 USA.
Bradley J NelsonInstitute of Robotics and Intelligent Systems ETH Zurich Zurich CH-8092 Switzerland.ORCID https://orcid.org/0000-0001-9070-6987
ETH Zurich · CHBoston Children's Hospital · US

Funding

European Research Council 743217
6 · The paper itself

Abstract

Patients suffering from heart failure often require circulatory support using ventricular assist devices (VADs). However, most existing VADs provide nonpulsatile flow, involve direct contact between the blood flow and the device's lumen and moving components, and require a driveline to connect to an external power source. These design features often lead to complications such as gastrointestinal bleeding, device thrombosis, and driveline infections. Here, a concept of magnetically active cardiac patches (MACPs) that can potentially function as non-blood contacting, untethered pulsatile VADs inside a magnetic actuationsystem is reported. The MACPs, which are composed of permanent magnets and 3D-printed patches, are attached to the epicardial surfaces, thus avoiding direct contact with the blood flow. They provide powerful actuation assisting native heart pumping inside a magnetic actuation system. In ex vivo experiments on a healthy pig's heart, it is shown that the ventricular ejection fractions are as high as 37% in the left ventricle and 63% in the right ventricle. Non-blood contacting, untethered VADs can eliminate the risk of serious complications associated with existing devices, and provide an alternative solution for myocardial training and therapy for patients with heart failure.

Indexed as

cardiac patchesmagnetic actuation systemsmagnetically active cardiac patchesuntethered devicesventricular assist devices

Identifiers

PMID33437567
PMCPMC7788498
OpenAlexW3109077945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.