Evidence map›Paper›PMID 33437465›Full record

SynthesisJournal of global health2020

What is the evidence for transmission of COVID-19 by children in schools? A living systematic review.

Wei Xu, Xue Li, Marshall Dozier, Yazhou He, Amir Kirolos, Zhongyu Lang, Catherine Mathews, Nandi Siegfried, Evropi Theodoratou, UNCOVER

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of global health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 6 pooled it
1.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 6 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
  2. SARS-CoV-2 Circulation in the School Setting: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
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  16. Community-based COVID-19 outbreak of the B.1.1.7 (Alpha) variant of concern in Newfoundland, February to March 2021.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Wei XuCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Xue LiCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Marshall DozierInformation Services, University of Edinburgh, Edinburgh, UK.
Yazhou HeCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Amir KirolosCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Zhongyu LangCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Catherine MathewsHealth Systems Research Unit, South African Medical Research Council, Parow, South Africa.
Nandi SiegfriedHealth Systems Research Unit, South African Medical Research Council, Parow, South Africa.
Evropi TheodoratouCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
UNCOVER
University of Edinburgh · GBSouth African Medical Research Council · ZAMedical Research Council · GBSecond Affiliated Hospital of Zhejiang University · CNUniversity of Liverpool · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundIt is of paramount importance to understand the transmission of SARS-CoV-2 in schools, which could support the decision-making about educational facilities closure or re-opening with effective prevention and control measures in place.

methodsWe conducted a systematic review and meta-analysis to investigate the extent of SARS-CoV-2 transmission in schools. We performed risk of bias evaluation of all included studies using the Newcastle-Ottawa Scale (NOS).

results2178 articles were retrieved and 11 studies were included. Five cohort studies reported a combined 22 student and 21 staff index cases that exposed 3345 contacts with 18 transmissions (overall infection attack rate (IAR): 0.08%, 95% confidence interval (CI) = 0.00%-0.86%). IARs for students and school staff were 0.15% (95% CI = 0.00%-0.93%) and 0.70% (95% CI = 0.00%-3.56%) respectively. Six cross-sectional studies reported 639 SARS-CoV-2 positive cases in 6682 study participants tested [overall SARS-CoV-2 positivity rate: 8.00% (95% CI = 2.17%-16.95%). SARS-CoV-2 positivity rate was estimated to be 8.74% (95% CI = 2.34%-18.53%) among students, compared to 13.68% (95% CI = 1.68%-33.89%) among school staff. Gender differences were not found for secondary infection (OR = 1.44, 95% CI = 0.50-4.14,

conclusionsThere is limited high-quality evidence available to quantify the extent of SARS-CoV-2 transmission in schools or to compare it to community transmission. Emerging evidence suggests lower IAR and SARS-CoV-2 positivity rate in students compared to school staff. Future prospective and adequately controlled cohort studies are necessary to confirm this finding.

Indexed as

SARS-CoV-2AdolescentChildCOVID-19Cross-Sectional StudiesDisease Transmission, InfectiousFemaleHumansMaleSchoolsStudents

Identifiers

PMID33437465
PMCPMC7774027
OpenAlexW3118965909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.