Correlation of Hypoxia-inducible facto-1α and C-reactive protein with disease evaluation in patients with ulcerative colitis.

Shuxia Yu, Bin Li, Jinghua Hao, Xiuju Shi, Jian Ge, Hongwei Xu

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Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed

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4 citing papers in PubMed.

Immunological pathogenesis of inflammatory bowel disease: focus on tissue resident memory T cells.Frontiers in immunology · 2025
Review
Interrelation of Hypoxia-Inducible Factor-1 Alpha (HIF-1 α) and the Ratio between the Mean Corpuscular Volume/Lymphocytes (MCVL) and the Cumulative Inflammatory Index (IIC) in Ulcerative Colitis.Biomedicines · 2023
Article
Enhanced oxidative phosphorylation of IgG plasma cells can contribute to hypoxia in the mucosa of active ulcerative colitis.Histochemistry and cell biology · 2022
Article
Artificial Neural Network Analysis-Based Immune-Related Signatures of Primary Non-Response to Infliximab in Patients With Ulcerative Colitis.Frontiers in immunology · 2021
Article

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6 authors.

Shuxia YuDepartment of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University Ji'nan, Shandong Province, China.

Bin LiDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University Ji'nan, Shandong Province, China.

Jinghua HaoDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University Ji'nan, Shandong Province, China.

Xiuju ShiDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University Ji'nan, Shandong Province, China.

Jian GeDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University Ji'nan, Shandong Province, China.

Hongwei XuDepartment of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University Ji'nan, Shandong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the expression levels of hypoxia-inducible factor-1α (HIF-1α) and C-reactive protein (CRP) in patients with ulcerative colitis and correlations of HIF-1α and CRP levels with disease severity.

methodsA total of 82 patients with confirmed ulcerative colitis were enrolled in this study and according to the disease severity grading, these patients were assigned into three groups: mild group (n=25), moderate group (n=31) and severe group (n=26). And other 30 patients without ulcerative colitis as demonstrated by colonoscopy examination were enrolled in control group in the same period. HIF-1α and CRP levels were detected by ELISA and Real-time PCR and compared among different groups. Pearson's correlation analysis was performed to evaluate the correlations of HIF-1α and CRP levels with disease severity. Logistic regression analysis was used to explore risk factors of disease severity in patients with ulcerative colitis.

resultsThe expression levels of HIF-1α and CRP in ulcerative colitis group were significantly higher than those in control group (all P<0.001). The levels of HIF-1α and CRP in patients with ulcerative colitis increased remarkably with the increase of disease severity. Patients in mild group had the lowest levels of HIF-1α and CRP, while patients in severe group had the highest levels of HIF-1α and CRP. Logistic regression analysis showed that the expression of HIF-1α and CRP were the risk factors for disease severity of ulcerative colitis (all P<0.001). And Pearson correlation analysis showed that HIF-1α and CRP levels were significantly associated with Rachmilewitz score and disease activity index (DAI), respectively (all P<0.001).

conclusionThe levels of HIF-1α and CRP were up-regulated in patients with ulcerative colitis and positively correlated with the progression of ulcerative colitis, indicating that the detection of HIF-1α and CRP expression could be used for predicting the disease severity.

Indexed as

correlationC-reactive proteinhypoxia-inducible factorUlcerative colitis

Identifiers

PMID33437363

PMCPMC7791512

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