Evidence map›Paper›PMID 33437352›Full record

ReviewAmerican journal of translational research2020

AMPK: implications in osteoarthritis and therapeutic targets.

Junjie Wang, Jiali Li, Deye Song, Jiangdong Ni, Muliang Ding, Jun Huang, Mingming Yan

Abstract readReview
PubMed Full text at PMC
In one paragraph

Review in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Junjie WangDepartment of Orthopaedic Surgery, The Second Xiangya Hospital of Central South University Changsha 410011, Hunan, China.
Jiali LiDepartment of Rheumatology and Nephrology, University of South China Affiliated Changsha Central Hospital Changsha 410008, Hunan, China.
Deye SongDepartment of Orthopaedic Surgery, The Second Xiangya Hospital of Central South University Changsha 410011, Hunan, China.
Jiangdong NiDepartment of Orthopaedic Surgery, The Second Xiangya Hospital of Central South University Changsha 410011, Hunan, China.
Muliang DingDepartment of Orthopaedic Surgery, The Second Xiangya Hospital of Central South University Changsha 410011, Hunan, China.
Jun HuangDepartment of Orthopaedic Surgery, The Second Xiangya Hospital of Central South University Changsha 410011, Hunan, China.
Mingming YanDepartment of Orthopaedic Surgery, The Second Xiangya Hospital of Central South University Changsha 410011, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is the most common skeletal disease and the leading cause of pain and disability in the aged population (>65 years). However, the underlying factors involved in OA pathogenesis remain elusive which has resulted in failure to identify disease-modifying OA drugs. Altered metabolism has been shown to be a prominent pathological change in OA. As a critical bioenergy sensor, AMP-activated protein kinase (AMPK) mediates not only energy homeostasis but also redox balance in chondrocytes to counter various cell stress. Dysfunction of AMPK activity has been associated with reduced autophagy, impaired mitochondrial function, excessive reactive oxygen species generation, and inflammation in joint tissue. These abnormalities ultimately trigger articular cartilage degeneration, synovial inflammation, and abnormal subchondral bone remodeling. This review focuses on recent findings describing the central role of AMPK in joint homeostasis and OA development. We also highlight current advances that target AMPK as a novel therapeutic strategy for OA prevention.

Indexed as

AMPKautophagyinflammationmetabolismOsteoarthritis

Identifiers

PMID33437352
PMCPMC7791500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.