ReviewInternational journal of medical sciences2021
Potential mechanisms linking psychological stress to bone health.
Review in International journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Early-life famine exposure and risk of osteoporosis and low bone mineral density: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Pooled it
- Acculturation and biological stress markers: A systematic review.Psychoneuroendocrinology · 2021Pooled it
- From depression to bone health: examining the skeletal effects of classical and rapid-acting antidepressants.The international journal of neuropsychopharmacology · 2026Review
- Associations of allergic diseases with incident hospital-recorded osteoporosis and major osteoporotic fracture in older adults: a prospective cohort study in the UK Biobank.BMC geriatrics · 2026Article
- Associations of gait speed, grip strength, depressive symptoms, and their combinations with fracture risk in older adults.GeroScience · 2026Article
- Pathophysiology and Molecular Signalling in Osteoporosis: Linking Risk Factors to Bone Loss.Journal of cellular and molecular medicine · 2026Review
- Alterations in bone-related hormones and genes expression in femoral bone of polycystic ovary syndrome rats.Journal of bone and mineral metabolism · 2026Article
- Japanese cancer survivors have a higher risk of fragility fractures over ten years.Scientific reports · 2026Article
- The PTSD-Bone Axis: Evidence, Mechanisms, and Management.Current osteoporosis reports · 2026Review
- Psychotropic medication use and bone loss in men: longitudinal study.BJPsych open · 2026Article
- Psychological Stress Modulates Bone Remodeling Pathways in Normotensive and Hypertensive Rats: A Cellular and Molecular Approach.ACS omega · 2026Article
- Longitudinal trajectories of total, cognitive-affective, and somatic depressive symptoms in relation to hip fracture risk: evidence from the HRS and ELSA cohorts.Frontiers in public health · 2026Article
- Interorgan Communications in Skeletal Pathophysiology: From Molecular Pathways to Multidisciplinary Therapies.Research (Washington, D.C.) · 2026Review
- Chronic low-grade inflammation drives skeletal aging and neurocognitive decline: inflammaging as a central hub coupling bone-brain aging.Frontiers in immunology · 2026Review
- Psychosomatic interplay in postmenopausal osteoporosis: from neuroendocrine mechanisms to structured psychological therapies and long-term management.Frontiers in psychiatry · 2026Review
- Association between kinesiophobia and bone mineral density in hospitalized older adults with osteoporosis: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Effects of a multicomponent intervention on body composition and cardiovascular risk factors in women with obesity- a randomized clinical trial.Journal of diabetes and metabolic disorders · 2025Article
- Review
- What is the impact of stress on the development of molar incisor hypomineralization (MIH): a systematic review.The Saudi dental journal · 2025Review
- Stress During Lactation: A Hidden Link to Offspring Bone Health.Calcified tissue international · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic psychological stress affects many body systems, including the skeleton, through various mechanisms. This review aims to provide an overview of the factors mediating the relationship between psychological stress and bone health. These factors can be divided into physiological and behavioural changes induced by psychological stress. The physiological factors involve endocrinological changes, such as increased glucocorticoids, prolactin, leptin and parathyroid hormone levels and reduced gonadal hormones. Low-grade inflammation and hyperactivation of the sympathetic nervous system during psychological stress are also physiological changes detrimental to bone health. The behavioural changes during mental stress, such as altered dietary pattern, cigarette smoking, alcoholism and physical inactivity, also threaten the skeletal system. Psychological stress may be partly responsible for epigenetic regulation of skeletal development. It may also mediate the relationship between socioeconomic status and bone health. However, more direct evidence is required to prove these hypotheses. In conclusion, chronic psychological stress should be recognised as a risk factor of osteoporosis and stress-coping methods should be incorporated as part of the comprehensive osteoporosis-preventing strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.