Evidence map›Paper›PMID 33437158›Full record

ArticleJournal of ginseng research2021

Korean Red Ginseng aqueous extract improves markers of mucociliary clearance by stimulating chloride secretion.

Do-Yeon Cho, Daniel Skinner, Shaoyan Zhang, Ahmed Lazrak, Dong Jin Lim, Christopher G Weeks, Catherine G Banks, Chang Kyun Han, Si-Kwan Kim, Guillermo J Tearney and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of ginseng research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Red ginseng aqueous extract improves mucociliary transport dysfunction and histopathology in CF rat airways.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Do-Yeon ChoDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Daniel SkinnerDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Shaoyan ZhangDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Ahmed LazrakGregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Dong Jin LimDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Christopher G WeeksDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Catherine G BanksDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Chang Kyun HanKorea Ginseng Research Institute, Korea Ginseng Corporation, Daejeon, Republic of Korea.
Si-Kwan KimDepartment of Biomedical Chemistry, Konkuk University, Chungju, Republic of Korea.
Guillermo J TearneyWellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States.
Sadis MatalonGregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Steven M RoweGregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Bradford A WoodworthDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.
University of Alabama at Birmingham · USKonkuk University · KRMassachusetts General Hospital · US

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Brian R. Davis · 2007 to 2026
$23.0M
Translational Program in CFTR-Related Airway DiseasesR35HL135816 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROWE, STEVEN MARK · 2017 to 2022
$6.3M
Bromine Inhalation Induced Lung Injury: Novel Mechanisms and Treatment StrategiesU01ES026458 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MATALON, SADIS · 2015 to 2019
$3.9M
Ivacaftor for Acquired CFTR Dysfunction in Chronic RhinosinusitisR01HL133006 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WOODWORTH, BRADFORD ALAN · 2016 to 2020
$1.7M
NHLBI NIH HHS R01 HL133006NHLBI NIH HHS R35 HL135816NIDDK NIH HHS P30 DK072482NIEHS NIH HHS U01 ES026458
6 · The paper itself

Abstract

backgroundAbnormal chloride (Cl

methodsPrimary murine nasal septal epithelial (MNSE) [wild-type (WT) and transgenic CFTR

resultsRGAE (at 30μg/mL of ginsenosides) significantly increased Cl

conclusionRGAE augments ASL depth and CBF by stimulating Cl

Indexed as

CFTRChloride channelsMucociliary clearanceRed GinsengSinusitis

Identifiers

PMID33437158
PMCPMC7790903
OpenAlexW2972980464

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.