Evidence map›Paper›PMID 33437026›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2021

Serum biomarkers, skin autofluorescence and other methods. Which parameter better illustrates the relationship between advanced glycation end products and arterial stiffness in the general population?

Július Gelžinský, Otto Mayer, Jitka Seidlerová, Markéta Mateřánková, Štěpán Mareš, Veronika Kordíkova, Ladislav Trefil, Renata Cífková, Jan Filipovský

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In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. The Role of Advanced Glycation End Products in Saphenous Vein Graft Failure.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Aging of the Arterial System.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Vascular Aging: Assessment and Intervention.Clinical interventions in aging · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Annual reports on hypertension research 2020.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Július Gelžinský2nd Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic. gelzinskyj@fnplzen.cz.
Otto Mayer2nd Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic.
Jitka Seidlerová2nd Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic.
Markéta Mateřánková2nd Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic.
Štěpán Mareš2nd Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic.
Veronika Kordíkova2nd Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic.
Ladislav TrefilDepartment of Clinical Biochemistry and Hematology, University Hospital, Pilsen, Czech Republic.
Renata CífkováCentre for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic.
Jan Filipovský2nd Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic.
Charles University · CZUniversity Hospital Brno · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stiffening of large arteries, clinically manifesting as increased aortic pulse wave velocity (PWV), is an inevitable outcome of aging. Among other mechanisms, impaired glucose metabolism plays an important role, leading to the deposition of advanced glycation end products (AGEs). This process is counterbalanced by the circulating soluble receptor for AGEs (sRAGE). We investigated the association between arterial stiffness on one side and multiple circulating biomarkers and the degree of skin deposition of AGEs on the other. In a cross-sectional design, 867 participants based on a general population sample (Czech post-MONICA studies) were examined. PWV was measured by SphygmoCor device (AtCor Medical Ltd.), while skin AGEs were measured using a dedicated autofluorescence method (AGE Reader mu

Indexed as

Glycation End Products, AdvancedVascular StiffnessBiomarkersCross-Sectional StudiesFluorescenceHumansReproducibility of ResultsSkin Physiological PhenomenaBiomarkersGlycation End Products, AdvancedAGEsCarboxymethyl lysineGlucose metabolismPulse wave velocitySRAGE

Identifiers

PMID33437026
OpenAlexW3120094399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.