ArticleMolecular psychiatry2021
Incomplete hippocampal inversion in schizophrenia: prevalence, severity, and impact on hippocampal structure.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Characterizing Interthalamic Adhesion Morphology in Schizophrenia: Associations With Aging, Neuropsychological Functioning, and Atypical Hippocampal Development.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Microglia-derived metabolites as novel signaling molecules: regulating neural circuit function, behavior, and their role in psychiatric disorders.Frontiers in cellular neuroscience · 2026Review
- Hippocampal volume in affective and non-affective psychosis.Schizophrenia research · 2025Article
- Balancing Efficacy and Safety: Transcranial Direct Current Stimulation as an Adjunctive Intervention for Persistent Auditory Verbal Hallucinations in a Case of Schizophrenia and Seizure Disorder with Incomplete Hippocampal Inversion.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Identification of bilateral fornix and hippocampus in fetuses between 18-36 gestational weeks and establishment of nomograms using ultrasonography.Archives of gynecology and obstetrics · 2025Article
- Automatic rating of incomplete hippocampal inversions evaluated across multiple cohorts.ArXiv · 2025Article
- 3D histological mapping of hippocampal subfields: a comparative study in patients with schizophrenia and healthy controls.Frontiers in psychiatry · 2025Article
- Schizophrenia-Like Deficits and Impaired Glutamate/Gamma-aminobutyric acid Homeostasis in Zfp804a Conditional Knockout Mice.Schizophrenia bulletin · 2024Article
- Intrinsic Infant Hippocampal Function Supports Inhibitory Processing.Developmental psychobiology · 2024Article
- Longitudinal study on hippocampal subfields and glucose metabolism in early psychosis.Schizophrenia (Heidelberg, Germany) · 2024Article
- Epigenome Defines Aberrant Brain Laterality in Major Mental Illnesses.Brain sciences · 2024Review
- Smaller anterior hippocampal subfields in the early stage of psychosis.Translational psychiatry · 2024Article
- Modelling the overlap and divergence of autistic and schizotypal traits on hippocampal subfield volumes and regional cerebral blood flow.Molecular psychiatry · 2024Article
- Hippocampal rotation is associated with ventricular atrial size.Pediatric radiology · 2023Article
- Lack of correlation between hippocampal substructure atrophy and attention dysfunction in deficit schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Incomplete Hippocampal Inversion: A Neurodevelopmental Mechanism for Hippocampal Shape Deformation in Schizophrenia.Biological psychiatry · 2022Article
- Article
- Structural and Functional Deviations of the Hippocampus in Schizophrenia and Schizophrenia Animal Models.International journal of molecular sciences · 2022Review
- Electroacupuncture alleviates orofacial allodynia and anxiety-like behaviors by regulating synaptic plasticity of the CA1 hippocampal region in a mouse model of trigeminal neuralgia.Frontiers in molecular neuroscience · 2022Article
- Automated, open-source segmentation of the Hippocampus and amygdala with the open Vanderbilt archive of the temporal lobe.Magnetic resonance imaging · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Incomplete hippocampal inversion (IHI) is an anatomical variant of the human brain resulting from an arrest in brain development, especially prevalent in the left hemisphere. We hypothesized that IHI is more common in schizophrenia and contributes to the well-known hippocampal structural differences. We studied 199 schizophrenia patients and 161 healthy control participants with 3 T MRI to establish IHI prevalence and the relationship of IHI with hippocampal volume and asymmetry. IHI was more prevalent (left hemisphere: 15% of healthy control participants, 27% of schizophrenia patients; right hemisphere: 4% of healthy control participants, 10% of schizophrenia patients) and more severe in schizophrenia patients compared to healthy control participants. Severe IHI cases were associated with a higher rate of automated segmentation failure. IHI contributed to smaller hippocampal volume and increased R > L volume asymmetry in schizophrenia. The increased prevalence and severity of IHI supports the neurodevelopmental model of schizophrenia. The impact of this developmental variant deserves further exploration in studies of the hippocampus in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.