ArticleScientific reports2021
Temperature induced changes in the optical properties of skin in vivo.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Integrated device for optoacoustically-guided ultrasound surgery.Nature communications · 2026Article
- Numerical optimization of laser radius ratio and power in photothermal therapy of various ellipsoidal tumor shape.Discover nano · 2026Article
- Thermal damage induced changes in optical properties of the porcine dermis.Journal of biomedical optics · 2025Article
- Anisotropic light propagation in human brain white matter.Neurophotonics · 2025Article
- Effects of cold storage on double integrating sphere optical property measurements of porcine dermis and subcutaneous fat from 400 to 1100 nm.Journal of biomedical optics · 2025Article
- Evaluation and Validation on Sensitivity of Near-Infrared Diffuse Reflectance in Non-Invasive Human Blood Glucose Measurement.Sensors (Basel, Switzerland) · 2024Article
- 3D modeling of in vivo MRI-guided nano-photothermal therapy mediated by magneto-plasmonic nanohybrids.Biomedical engineering online · 2023Article
- Relevance and utility of theBiomedical optics express · 2023Review
- Stochastic three-dimensional numerical phantoms to enable computational studies in quantitative optoacoustic computed tomography of breast cancer.Journal of biomedical optics · 2023Article
- Light distribution in fat cell layers at physiological temperatures.Scientific reports · 2023Article
- A New Nonlinear Photothermal Iterative Theory for Port-Wine Stain Detection.International journal of environmental research and public health · 2022Article
- Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects.Materials (Basel, Switzerland) · 2022Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowledge of temperature-induced changes of skin optical properties is required for accurate dosimetry of photothermal treatments. We determined and compared in vivo optical properties of mouse ear skin at different temperatures. The diffuse reflectance, total and diffuse transmittance were measured in the spectral range from 400 to 1650 nm using an integrating sphere spectrometer at the temperatures of 25 °C, 36 °C and 60 °C. Target temperatures were attained and maintained using an automated heater equipped with a sensor for feed-back and control. Temperature and temperature induced morphological changes of skin were monitored using an infrared thermal camera and reflectance confocal microscopy, respectively. An inverse Monte Carlo technique was utilized to determine absorption, scattering, and anisotropy factors from the measured quantities. Our results indicate significant differences between the optical properties of skin at different temperatures. Absorption and scattering coefficients increased, whereas anisotropy factors decreased with increasing temperature. Changes in absorption coefficients indicate deoxygenation of hemoglobin, and a blue shift of water absorption bands. Confocal imaging confirmed that our observations can be explained by temperature induced protein denaturation and blood coagulation. Monitoring spectral responses of treated tissue may become a valuable tool for accurate dosimetry of light treatments.
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