ArticleScientific reports2021
Increased risk of major depressive disorder in sleep apnea patients in Taiwan.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Associations between body composition, hydration status, and sleep architecture in obstructive sleep apnea.Frontiers in endocrinology · 2025Article
- The Population Based Risk of Obstructive Sleep Apnea and Psychiatric Conditions.Depression and anxiety · 2025Article
- Shift work, clinically significant sleep disorders and mental health in a representative, cross-sectional sample of young working adults.Scientific reports · 2022Article
- Risk of pneumothorax in pneumoconiosis patients in Taiwan: a retrospective cohort study.BMJ open · 2021Article
- Performance Assessment of Certain Machine Learning Models for Predicting the Major Depressive Disorder among IT Professionals during Pandemic times.Computational intelligence and neuroscience · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between sleep apnea (SA) and depression had been reported in a few previous studies. However, whether SA increases the risk of major depressive disorder (MDD) has not been studied comprehensively in a large-scale study. We performed this population-based cohort study to assess the association between SA and MDD. We identified adult patients having SA from the Taiwan National Health Insurance Research Database and excluded those having MDD before SA diagnosis. Thirty control subjects were randomly selected to match to each SA patient by age and sex. Totally, 10,259 SA patients were matched to 102,590 control subjects. The incidence rate and cumulative incidence of MDD were significantly higher in SA patients than in the control subjects (both p < 0.0001). Multivariable Cox regression analysis showed that SA remained an independent risk factor for incident MDD after adjusting for age, sex, residency, income level, and comorbidities (hazard ratio = 2.9 [95% CI 2.8-3.1], p < 0.0001). In summary, SA patients have an increased risk to develop MDD. Physicians caring for SA patients must pay attention to their psychosocial health status.
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