ArticleScientific reports2021
The effects of maternal separation on behaviours under social-housing environments in adult male C57BL/6 mice.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Early life adversity disrupts adult social reward motivation.bioRxiv : the preprint server for biology · 2026Article
- Maternal separation-induced changes in breast milk fatty acid composition are associated with altered gut microbiota and serotonergic gene expression in neonatal mice.Molecular biomedicine · 2026Article
- IntelliProfiler: a research workflow for analyzing multiple animals with a high-resolution home-cage RFID system.Lab animal · 2026Article
- A history of maternal separation drives systemic aging-associated signatures in middle-aged male rats.Frontiers in cellular neuroscience · 2026Article
- Preimplantational ethanol exposure causes disturbances in gene expression and abnormalities in cerebral cortex morphogenesis and behavior.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- The therapeutic effects ofGut microbiome (Cambridge, England) · 2025Review
- Brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior.Molecular psychiatry · 2024Article
- Chronic Stress in Early Development and Effects on Traumatic Brain Injury Outcome.Advances in neurobiology · 2024Review
- Connexin 43 regulates astrocyte dysfunction and cognitive deficits in early life stress-treated mice.Experimental brain research · 2023Article
- Effects of early maternal separation on the expression levels of hippocampal and prefrontal cortex genes and pathways in lactating piglets.Frontiers in molecular neuroscience · 2023Article
- Blueprints for measuring natural behavior.iScience · 2022Review
- Is It Possible to Shift from Down to Top Rank? A Focus on the Mesolimbic Dopaminergic System and Cocaine Abuse.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse experience in early life can affect the formation of neuronal circuits during postnatal development and exert long-lasting influences on neural functions that can lead to the development of a variety of psychiatric disorders including depression, anxiety disorders, and post-traumatic stress disorder. Many studies have demonstrated that daily repeated maternal separation, an animal model of early-life stress, can induce impairments in emotional behaviours and cognitive function during adolescence and adulthood. However, the behavioural phenotypes of maternally separated mice under long-term group-housing conditions are largely unknown. In this study, we applied our newly developed assay system to investigate the effects of maternal separation on behaviours under group-housing conditions during four days of continuous observations. Using our system, we found that repeated maternal separation resulted in inappropriate social distance from cagemates, altered approach preferences to others, and induced a lower rank in the time spent on the running wheel under group-housing conditions in adult male mice. Focussing on these behavioural abnormalities that appear in an environment with a social context will be important insights to understand the pathogenesis of psychiatric disorders.
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