ArticleScientific reports2021
First report on antibiotic resistance and antimicrobial activity of bacterial isolates from 13,000-year old cave ice core.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 52 citations in OpenAlex.
- Evaluating packaged ice safety using culture-based and metagenomic methods.Microbiology (Reading, England) · 2026Article
- Evaluating the Impact of Little Cigar Use on the Oral Bacterial Microbiota of Cigarette Smokers.Pathogens (Basel, Switzerland) · 2026Article
- Metagenomic analysis of bacterial diversity, antibiotic resistance, and functional profiles in the ice core samples from two glaciers of Sikkim Himalaya.Scientific reports · 2026Article
- Revolutionizing Antibiotic Delivery: Harnessing 3D-Printing Technology to Combat Bacterial Resistance.Current pharmaceutical design · 2026Review
- A correlation analysis between arsenic and mercury resistance and the spread of antibiotic resistance genes in bacteria isolated from a highly contaminated brownfield.Frontiers in microbiology · 2026Article
- Reassessing the role of wild birds in the spread of antibiotic resistance: the white stork as a model species in studying populations from Central European river valley.Microbiology spectrum · 2025Article
- Diversity of antibiotic resistance genes and mobile genetic elements of Sof Umer Cave microbiomes, Ethiopia.BMC genomic data · 2025Article
- Differences in composition and potential function of the bacterial communities of cave- and surface-dwelling Mexican salamanders.Animal microbiome · 2025Article
- High antagonistic activity and antibiotic resistance of flavobacteria of polar microbial freshwater mats on King George Island in maritime Antarctica.Scientific reports · 2025Article
- Reassessing sepsis research: new clues for old players and new players for an old symptom to improve patient outcomes.EXCLI journal · 2025Review
- First genome sequence and functional profiling ofFrontiers in microbiology · 2025Article
- Characterizing the resistome ofFrontiers in microbiology · 2025Article
- Exploring the bacterial diversity and its antibiotic resistance in Kabru Glacier ice cores, Sikkim Himalaya.Frontiers in microbiology · 2025Article
- Cold-Active Lipase from the Ice CaveMolecules (Basel, Switzerland) · 2024Article
- Geothermal ecosystems on Mt. Erebus, Antarctica, support diverse and taxonomically novel biota.FEMS microbiology ecology · 2024Article
- Dissemination and persistence of antimicrobial resistance (AMR) along the wastewater-river continuum.Water research · 2024Article
- Differential effects of winter cold stress on soil bacterial communities, metabolites, and physicochemical properties in two varieties ofMicrobiology spectrum · 2024Article
- Molecular de-extinction of ancient antimicrobial peptides enabled by machine learning.Cell host & microbe · 2023Article
- Identification of diverse antibiotic resistant bacteria in agricultural soil with HEnvironmental microbiome · 2023Article
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4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the unique physiology and metabolic pathways of microbiomes from cold environments providing key evolutionary insights and promising leads for discovering new bioactive compounds, cultivable bacteria entrapped in perennial ice from caves remained a largely unexplored life system. In this context, we obtained and characterized bacterial strains from 13,000-years old ice core of Scarisoara Ice Cave, providing first isolates from perennial ice accumulated in caves since Late Glacial, and first culture-based evidences of bacterial resistome and antimicrobial compounds production. The 68 bacterial isolates belonged to 4 phyla, 34 genera and 56 species, with 17 strains representing putative new taxa. The Gram-negative cave bacteria (Proteobacteria and Bacteroidetes) were more resistant to the great majority of antibiotic classes than the Gram-positive ones (Actinobacteria, Firmicutes). More than 50% of the strains exhibited high resistance to 17 classes of antibiotics. Some of the isolates inhibited the growth of clinically important Gram-positive and Gram-negative resistant strains and revealed metabolic features with applicative potential. The current report on bacterial strains from millennia-old cave ice revealed promising candidates for studying the evolution of environmental resistome and for obtaining new active biomolecules for fighting the antibiotics crisis, and valuable cold-active biocatalysts.
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