ArticleScientific reports2021
Evaluation of wavelength ranges and tissue depth probed by diffuse reflectance spectroscopy for colorectal cancer detection.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 70 citations in OpenAlex.
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- Side-viewing probe for lesion depth mapping on the left ventricle epicardium with near-infrared spectroscopy.Scientific reports · 2026Article
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- Identification of colorectal malignancies enabled by phasor-based autofluorescence lifetime macroimaging and ensemble learning.Biophotonics discovery · 2025Article
- Evaluating Normalization Methods for Robust Spectral Performance Assessments of Hyperspectral Imaging Cameras.Biosensors · 2025Article
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- Study of Minor Chromophores in Biological Tissues by Diffuse Optical Spectroscopy (Review).Sovremennye tekhnologii v meditsine · 2025Review
- Towards a sensing model using a random laser combined with diffuse reflectance spectroscopy.Biomedical optics express · 2024Article
- Dual excitation spectral autofluorescence lifetime and reflectance imaging for fast macroscopic characterization of tissues.Biomedical optics express · 2024Article
- Evaluating the relationship between ocular blood flow and systemic organ blood flow in hemorrhagic shock using a rabbit model.Scientific reports · 2024Article
- Point Projection Mapping System for Tracking, Registering, Labeling, and Validating Optical Tissue Measurements.Journal of imaging · 2024Article
- Diffuse Reflectance Spectroscopy of the Oral Mucosa: In Vivo Experimental Validation of the Precancerous Lesions Early Detection Possibility.Diagnostics (Basel, Switzerland) · 2023Article
- Quantification of the Phenomena Affecting Reflective Arterial Photoplethysmography.Bioengineering (Basel, Switzerland) · 2023Article
- VIS-NIR Diffuse Reflectance Spectroscopy System with Self-Calibrating Fiber-Optic Probe: Study of Perturbation Resistance.Diagnostics (Basel, Switzerland) · 2023Article
- Diffuse reflection spectroscopy at the fingertip: design and performance of a compact side-firing probe for tissue discrimination during colorectal cancer surgery.Biomedical optics express · 2023Article
- Diffuse reflectance spectroscopy sensor to differentiate between glial tumor and healthy brain tissue: a proof-of-concept study.Biomedical optics express · 2022Article
- Label-Free Optical Spectroscopy for Early Detection of Oral Cancer.Diagnostics (Basel, Switzerland) · 2022Review
- Insights into Biochemical Sources and Diffuse Reflectance Spectral Features for Colorectal Cancer Detection and Localization.Cancers · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is the third most common type of cancer worldwide and the second most deadly. Recent research efforts have focused on developing non-invasive techniques for CRC detection. In this study, we evaluated the diagnostic capabilities of diffuse reflectance spectroscopy (DRS) for CRC detection by building 6 classification models based on support vector machines (SVMs). Our dataset consists of 2889 diffuse reflectance spectra collected from freshly excised ex vivo tissues of 47 patients over wavelengths ranging from 350 and 1919 nm with source-detector distances of 630-µm and 2500-µm to probe different depths. Quadratic SVMs were used and performance was evaluated using twofold cross-validation on 10 iterations of randomized training and test sets. We achieved (93.5 ± 2.4)% sensitivity, (94.0 ± 1.7)% specificity AUC by probing the superficial colorectal tissue and (96.1 ± 1.8)% sensitivity, (95.7 ± 0.6)% specificity AUC by sampling deeper tissue layers. To the best of our knowledge, this is the first DRS study to investigate the potential of probing deeper tissue layers using larger SDD probes for CRC detection in the luminal wall. The data analysis showed that using a broader spectrum and longer near-infrared wavelengths can improve the diagnostic accuracy of CRC as well as probing deeper tissue layers.
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