Evidence map›Paper›PMID 33436679›Full record

ArticleScientific reports2021

Integration of genome-wide association study and expression quantitative trait locus mapping for identification of endometriosis-associated genes.

Ya-Ching Chou, Ming-Jer Chen, Pi-Hua Chen, Ching-Wen Chang, Mu-Hsien Yu, Yi-Jen Chen, Eing-Mei Tsai, Shih-Feng Tsai, Wun-Syuan Kuo, Chii-Ruey Tzeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Identification ofComputational and structural biotechnology journal · 2023
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ya-Ching ChouDepartment of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
Ming-Jer ChenDepartment of Obstetrics and Gynecology and Women's Health, Taichung Veterans General Hospital, Taichung, Taiwan.
Pi-Hua ChenGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Ching-Wen ChangDepartment of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Mu-Hsien YuDepartment of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Yi-Jen ChenDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan.
Eing-Mei TsaiGeneral Research Centers of R&D Office, Kaohsiung Medical University, Kaohsiung, Taiwan.
Shih-Feng TsaiInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Wun-Syuan KuoDepartment of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chii-Ruey TzengCenter for Reproductive Medicine and Sciences, Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan. tzengcr@tmu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To determine whether genetic predisposition to endometriosis varies depending on ethnicity and in association with expression quantitative trait loci (eQTL) in a Taiwanese population. We conducted a genome-wide association study (GWAS) and replicated it in 259 individuals with laparoscopy-confirmed stage III or IV endometriosis (cases) and 171 women without endometriosis (controls). Their genomic DNA was extracted from blood and evaluated by the GWAS of Taiwan Biobank Array. Novel genetic variants that predispose individuals to endometriosis were identified using GWAS and replication, including rs10739199 (P = 6.75 × 10

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideQuantitative Trait LociAdultCase-Control StudiesChromosome MappingCytoskeletal ProteinsEndometriosisFemaleGenome-Wide Association StudyGenotypeHumansTaiwanCytoskeletal ProteinsINTU protein, human

Identifiers

PMID33436679
PMCPMC7803948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.