ArticleNature communications2021
Recurrent network dynamics shape direction selectivity in primary auditory cortex.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Large cranial windows distort auditory cortical maps and degrade feature integration in secondary auditory cortex.iScience · 2026Article
- Millimeter-scale selective amplification in the developing visual cortex.bioRxiv : the preprint server for biology · 2026Article
- Large cranial windows distort sensory maps and degrade feature integration in higher-order cortex.bioRxiv : the preprint server for biology · 2026Article
- Age-related decline in temporal sound processing: insights from envelope steepness map in the mouse auditory cortex.Frontiers in aging neuroscience · 2026Article
- Orthogonal spectral and temporal envelope representation during the onset phase in auditory cortex.iScience · 2025Article
- Interleaving asynchronous and synchronous activity in balanced cortical networks with short term synaptic depression.Nature communications · 2025Article
- Acute temporal lesions are associated with phonological word verification errors.Brain network disorders · 2025Article
- Untangling stability and gain modulation in cortical circuits with multiple interneuron classes.eLife · 2025Article
- Article
- A spatial code for temporal information is necessary for efficient sensory learning.Science advances · 2025Article
- Brain-inspired multisensory integration neural network for cross-modal recognition through spatiotemporal dynamics and deep learning.Cognitive neurodynamics · 2024Article
- Structural influences on synaptic plasticity: The role of presynaptic connectivity in the emergence of E/I co-tuning.PLoS computational biology · 2024Article
- Neuronal functional connectivity is impaired in a layer dependent manner near chronically implanted intracortical microelectrodes in C57BL6 wildtype mice.Journal of neural engineering · 2024Article
- A sparse code for natural sound context in auditory cortex.Current research in neurobiology · 2024Article
- Distinct nonlinear spectrotemporal integration in primary and secondary auditory cortices.Scientific reports · 2023Article
- Biological constraints on stereotaxic targeting of functionally-defined cortical areas.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Quantitative models of auditory cortical processing.Hearing research · 2023Review
- Distinct nonlinear spectrotemporal integration in primary and secondary auditory cortices.bioRxiv : the preprint server for biology · 2023Article
- Translaminar recurrence from layer 5 suppresses superficial cortical layers.Nature communications · 2022Article
- Inhibitory gating of coincidence-dependent sensory binding in secondary auditory cortex.Nature communications · 2021Article
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Authors and funding
6 authors.
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Abstract
Detecting the direction of frequency modulation (FM) is essential for vocal communication in both animals and humans. Direction-selective firing of neurons in the primary auditory cortex (A1) has been classically attributed to temporal offsets between feedforward excitatory and inhibitory inputs. However, it remains unclear how cortical recurrent circuitry contributes to this computation. Here, we used two-photon calcium imaging and whole-cell recordings in awake mice to demonstrate that direction selectivity is not caused by temporal offsets between synaptic currents, but by an asymmetry in total synaptic charge between preferred and non-preferred directions. Inactivation of cortical somatostatin-expressing interneurons (SOM cells) reduced direction selectivity, revealing its cortical contribution. Our theoretical models showed that charge asymmetry arises due to broad spatial topography of SOM cell-mediated inhibition which regulates signal amplification in strongly recurrent circuitry. Together, our findings reveal a major contribution of recurrent network dynamics in shaping cortical tuning to behaviorally relevant complex sounds.
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