ArticleTranslational psychiatry2021
Default mode and salience network alterations in suicidal and non-suicidal self-injurious thoughts and behaviors in adolescents with depression.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Altered Neural Activity in Adolescent Major Depressive Disorder With Nonsuicidal Self-Injury: A Resting-State Functional Magnetic Resonance Imaging Meta-Analysis.Neural plasticity · 2025Pooled it
- Aerobic Exercise and Subthreshold Depressive Symptoms in Adolescents: Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2026Trial
- Insular spontaneous activity changes after dialectical behavior therapy skills training for depressed patients with non-suicidal self-injury: a randomized controlled trial.BMC psychiatry · 2026Trial
- Effects of virtual reality eye movement desensitization and reprocessing therapy for adolescents with major depressive disorder: a functional Near-Infrared spectroscopy study.European child & adolescent psychiatry · 2026Trial
- Hierarchical neural variability reveals adaptive and maladaptive mechanisms of non-suicidal self-injury.Molecular psychiatry · 2026Article
- Exploring the mediating role of functional connectivity in the association between violence exposure and psychopathology during early adolescence.Brain and cognition · 2026Article
- Abnormal Dynamic Functional Connectivity Within the Fronto-Limbic Network Mediates the Association Between Depressive Symptoms and Non-Suicidal Self-Injury in Adolescents.CNS neuroscience & therapeutics · 2026Article
- Resting-state EEG default mode network connectivity and suicidal ideation in depressive disorders: a retrospective cross-sectional study.BMC psychiatry · 2026Article
- Treatment-related topological reorganization of the structural connectome in major depressive disorder with suicidal ideation.BMC psychiatry · 2026Article
- Altered functional brain network in adolescents with non-suicidal self-injury: a resting-state EEG study.BMC psychiatry · 2026Article
- High-gamma tACS may regulate brain network connectivity to alleviate symptoms in female adolescent non-suicidal self-injury: a preliminary TMS-EEG pilot study.BMC psychiatry · 2026Article
- Suicide attempt history, childhood trauma, and functional brain network alterations in major depressive disorder: a resting-state functional connectivity-based multivariate pattern analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Functional heterogeneity in non-suicidal self-injury across psychiatric disorders: neural and psychosocial correlates.Translational psychiatry · 2026Article
- Structural-functional connectivity decoupling reveals neural differences associated with subtypes of nonsuicidal self-injury among female depressive adolescents.Frontiers in psychiatry · 2026Article
- Exploring Brain Network Dynamics in Suicide Attempt Survivors Using EEG Microstate Analysis.Brain topography · 2025Article
- Attachment insecurity, adverse childhood experiences (ACEs), and suicidality in French residential-care adolescents: a gender-differentiated study.Child and adolescent psychiatry and mental health · 2025Article
- From brain to behavior: Psychological resilience mediates associations between whole-brain resting-state connectivity and NSSI.Dialogues in clinical neuroscience · 2025Article
- Neurobehavioral pathways linking socioeconomic status hardship to suicide risk versus resilience in young adolescents: the roles of sleep health and default mode network connectivity.Translational psychiatry · 2025Article
- Can you feel it? Altered affective touch perception in a transdiagnostic sample of female adolescents with nonsuicidal self-injury.Translational psychiatry · 2025Article
- Abnormal functional network connectivity mediates the relationship between depressive symptoms and cognitive decline in late-onset depression.Psychological medicine · 2025Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Suicidal ideation (SI) and non-suicidal self-injury (NSSI) are two distinct yet often co-occurring risk factors for suicide deaths in adolescents. Elucidating the neurobiological patterns that specifically characterize SI and NSSI in adolescents is needed to inform the use of these markers in intervention studies and to develop brain-based treatment targets. Here, we clinically assessed 70 adolescents-49 adolescents with depression and 21 healthy controls-to determine SI and NSSI history. Twenty-eight of the depressed adolescents had a history of SI and 29 had a history of NSSI (20 overlapping). All participants underwent a resting-state fMRI scan. We compared groups in network coherence of subdivisions of the central executive network (CEN), default mode network (DMN), and salience network (SN). We also examined group differences in between-network connectivity and explored brain-behavior correlations. Depressed adolescents with SI and with NSSI had lower coherence in the ventral DMN compared to those without SI or NSSI, respectively, and healthy controls (all ps < 0.043, uncorrected). Depressed adolescents with NSSI had lower coherence in the anterior DMN and in insula-SN (all ps < 0.030, uncorrected), and higher CEN-DMN connectivity compared to those without NSSI and healthy controls (all ps < 0.030, uncorrected). Lower network coherence in all DMN subnetworks and insula-SN were associated with higher past-month SI and NSSI (all ps < 0.001, uncorrected). Thus, in our sample, both SI and NSSI are related to brain networks associated with difficulties in self-referential processing and future planning, while NSSI specifically is related to brain networks associated with disruptions in interoceptive awareness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.