ArticleBMJ open2021
Clinical features and natural history of the first 2073 suspected COVID-19 cases in the Corona São Caetano primary care programme: a prospective cohort study.
Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Global prevalence and effect of comorbidities and smoking status on severity and mortality of COVID-19 in association with age and gender: a systematic review, meta-analysis and meta-regression.Scientific reports · 2023Pooled it
- Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.The Cochrane database of systematic reviews · 2022Pooled it
- Self-reported olfactory and gustatory dysfunction and psychophysical testing in screening for COVID-19: A systematic review and meta-analysis.International forum of allergy & rhinology · 2022Pooled it
- Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.The Cochrane database of systematic reviews · 2021Pooled it
- SARS-CoV-2 lineage-specific disease symptoms and disease severity in a city in southeastern Brazil.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
- An after-action review of COVID-19 cases and mitigation measures at US Mission India, March 2020-July 2021.PLOS global public health · 2025Article
- Scale-free dynamics of COVID-19 in a Brazilian city.Applied mathematical modelling · 2023Article
- Association between development of severe COVID-19 and a polymorphism in the CIAS1 gene that codes for an inflammasome component.Scientific reports · 2023Article
- Article
- Detailed characterization of Redondovirus in saliva of SARS-CoV-2-infected individuals in Sao Paulo, Brazil.PloS one · 2023Article
- Thinking out of the box: revisiting health surveillance based on medical records.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Clinical Spectrum of Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Protection From Symptomatic Reinfection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Evaluation of the effectiveness of surveillance policies to control the COVID-19 pandemic in São Paulo, Brazil.Global health research and policy · 2022Article
- COVID-19 in Latin America and the caribbean region: Symptoms and morbidities in the epidemiology of infection.Current opinion in pharmacology · 2022Review
- Risk assessment and rationalization of health resource allocation: Lessons from the Brazilian COVID-19 cohort in 2020.Preventive medicine reports · 2022Article
- Exploring the Clinical Utility of Gustatory Dysfunction (GD) as a Triage Symptom Prior to Reverse Transcription Polymerase Chain Reaction (RT-PCR) in the Diagnosis of COVID-19: A Meta-Analysis and Systematic Review.Life (Basel, Switzerland) · 2021Review
- SARS-CoV-2 IgG seropositivity in a cohort of 449 non-hospitalized individuals during Spanish COVID-19 lockdown.Scientific reports · 2021Observational
- Prolonged presence of replication-competent SARS-CoV-2 in mildly symptomatic individuals: A report of two cases.Journal of medical virology · 2021Article
- A Novel Saliva RT-LAMP Workflow for Rapid Identification of COVID-19 Cases and Restraining Viral Spread.Diagnostics (Basel, Switzerland) · 2021Article
- Article
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Authors and funding
17 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundDespite most cases not requiring hospital care, there are limited community-based clinical data on COVID-19.
methodsThe Corona São Caetano programme is a primary care initiative providing care to all residents with COVID-19 in São Caetano do Sul, Brazil. It was designed to capture standardised clinical data on community COVID-19 cases. After triage of potentially severe cases, consecutive patients presenting to a multimedia screening platform between 13 April and 13 May 2020 were tested at home with SARS-CoV-2 reverse transcriptase (RT) PCR; positive patients were followed up for 14 days with phone calls every 2 days. RT-PCR-negative patients were offered additional SARS-CoV-2 serology testing to establish their infection status. We describe the clinical, virological and natural history features of this prospective population-based cohort.
findingsOf 2073 suspected COVID-19 cases, 1583 (76.4%) were tested by RT-PCR, of whom 444 (28.0%, 95% CI 25.9 to 30.3) were positive; 604/1136 (53%) RT-PCR-negative patients underwent serology, of whom 52 (8.6%) tested SARS-CoV-2 seropositive. The most common symptoms of confirmed COVID-19 were cough, fatigue, myalgia and headache; whereas self-reported fever (OR 3.0, 95% CI 2.4 to 3.9), anosmia (OR 3.3, 95% CI 2.6 to 4.4) and ageusia (OR 2.9, 95% CI 2.3 to 3.8) were most strongly associated with a positive COVID-19 diagnosis by RT-PCR or serology. RT-PCR cycle thresholds were lower in men, older patients, those with fever and arthralgia and closer to symptom onset. The rates of hospitalisation and death among 444 RT-PCR-positive cases were 6.7% and 0.7%, respectively, with older age and obesity more frequent in the hospitalised group.
conclusionCOVID-19 presents in a similar way to other mild community-acquired respiratory diseases, but the presence of fever, anosmia and ageusia can assist the specific diagnosis. Most patients recovered without requiring hospitalisation with a low fatality rate compared with other hospital-based studies.
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