ReviewRegional anesthesia and pain medicine2021
Pain management after open liver resection: Procedure-Specific Postoperative Pain Management (PROSPECT) recommendations.
Review in Regional anesthesia and pain medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Early postoperative pain and opioid use after liver surgery: A systematic review and meta-analysis.The Journal of international medical research · 2026Pooled it
- The Role of Surgical Techniques in Reducing Postoperative Pain in Abdominal Surgery: Evidence From the PROSPECT Systematic Reviews.World journal of surgery · 2025Pooled it
- The effects of virtual reality technology on reducing pain in wound care: A meta-analysis and systematic review.International wound journal · 2022Pooled it
- Ultrasound-guided External Oblique Intercostal Plane Block with Ropivacaine for Analgesia after Open Hepatectomy: A Randomized Controlled Study.Anesthesiology · 2026Trial
- ED95 of Liposomal Bupivacaine for Postoperative Local Infiltration Analgesia in Women Undergoing Cesarean Section: A Randomized Controlled Trial.Drug design, development and therapy · 2026Trial
- Ultrasound-Guided Modified Thoracoabdominal Nerve Block Through Perichondrial Approach for Postoperative Analgesia Management in Living Liver Donors: A Randomized, Prospective, Controlled Study.Clinical transplantation · 2025Trial
- Trial
- A randomized controlled trial to compare the effect of oxycodone and sufentanil on postoperative analgesia and immune function for laparoscopic resection of colorectal cancer.BMC anesthesiology · 2025Trial
- Effect of External Oblique Intercostal Block on Postoperative Analgesia and Early Recovery in Patients Undergoing Open Liver Resection for Hepatocellular Carcinoma or Intrahepatic Bile Duct Stones: A Randomized Controlled Clinical Trial.Local and regional anesthesia · 2025Trial
- Efficacy of Unilateral External Oblique Intercostal Fascial Plane Block Versus Subcostal TAP Block in Laparoscopic Cholecystectomy: Randomized, Prospective Study.Surgical innovation · 2024Trial
- Intravenous ibuprofen versus ketorolac for perioperative pain control in open abdominal hysterectomy: a randomized controlled trial.BMC anesthesiology · 2024Trial
- Dexmedetomidine Attenuates Inflammation in Elderly Patients Following Major Hepatobiliary and Pancreatic Surgery: A Randomized Clinical Trial.Clinical interventions in aging · 2024Trial
- Assessment of Ultrasound-Guided Continuous Low Serratus Anterior Plane Block for Pain Management After Hepatectomy: A Randomized Controlled Trial.Journal of pain research · 2023Trial
- Continuous Erector Spinae Plane Block Using Programmed Intermittent Bolus Regimen versus Intravenous Patient-Controlled Opioid Analgesia Within an Enhanced Recovery Program After Open Liver Resection in Patients with Coagulation Disorder: A Randomized, Controlled, Non-Inferiority Trial.Drug design, development and therapy · 2022Trial
- Preemptive nalbuphine combined with subcostal transversus abdominis plane block for multimodal analgesia in laparoscopic liver resection: a randomized controlled trial of multimodal analgesia for laparoscopic hepatectomy.Clinics (Sao Paulo, Brazil) · 2026Article
- Article
- Development and Evaluation of Clinical Practice Guidelines for Patients Undergoing Hepatectomy.Healthcare (Basel, Switzerland) · 2026Article
- Which fascial plane block is right for my patient? A practical decision-making algorithm for abdominal surgery.Journal of anesthesia, analgesia and critical care · 2026Review
- Mediation of postoperative length of stay by major adverse cardiovascular events in elderly patients underwent major thoracic and abdominal surgery receiving peripheral nerve blocks.BMC anesthesiology · 2026Article
- Postoperative complications after vacuum-assisted excision of benign breast tumors and their associated risk factors.Medicine · 2026Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesEffective pain control improves postoperative rehabilitation and enhances recovery. The aim of this review was to evaluate the available evidence and to develop recommendations for optimal pain management after open liver resection using Procedure-Specific Postoperative Pain Management (PROSPECT) methodology. STRATEGY AND SELECTION CRITERIA: Randomized controlled trials (RCTs) published in the English language from January 2010 to October 2019 assessing pain after liver resection using analgesic, anesthetic or surgical interventions were identified from MEDLINE, Embase and Cochrane databases.
resultsOf 121 eligible studies identified, 31 RCTs and 3 systematic reviews met the inclusion criteria. Preoperative and intraoperative interventions that improved postoperative pain relief were non-steroidal anti-inflammatory drugs, continuous thoracic epidural analgesia, and subcostal transversus abdominis plane (TAP) blocks. Limited procedure-specific evidence was found for intravenous dexmedetomidine, intravenous magnesium, intrathecal morphine, quadratus lumborum blocks, paravertebral nerve blocks, continuous local anesthetic wound infiltration and postoperative interpleural local anesthesia. No evidence was found for intravenous lidocaine, ketamine, dexamethasone and gabapentinoids.
conclusionsBased on the results of this review, we suggest an analgesic strategy for open liver resection, including acetaminophen and non-steroidal anti-inflammatory drugs, combined with thoracic epidural analgesia or bilateral oblique subcostal TAP blocks. Systemic opioids should be considered as rescue analgesics. Further high-quality RCTs are needed to confirm and clarify the efficacy of the recommended analgesic regimen in the context of an enhanced recovery program.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.