Evidence map›Paper›PMID 33436433›Full record

ArticlemBio2021

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa

Dina A Moustafa, Ashley W Wu, Danniel Zamora, Seth M Daly, Carolyn R Sturge, Christine Pybus, Bruce L Geller, Joanna B Goldberg, David E Greenberg

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 40 citations in OpenAlex.

  1. GrowingInfection and immunity · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Antimicrobial Resistance: The Answers.British journal of biomedical science · 2026
    Review
  6. Article
  7. Highly Conserved Genetic Factors RegulatingJournal of microbiology and biotechnology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Chemical strategies for antisense antibiotics.Chemical Society reviews · 2024
    Review
  12. Chronic hyperglycemia aggravates lung function in aAmerican journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Antibacterial peptide Reg4 amelioratesMicrobiology spectrum · 2024
    Article
  17. Review
  18. Article
  19. Sequence specificity defines the effectiveness of PPMOs targetingAntimicrobial agents and chemotherapy · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Dina A MoustafaDepartment of Pediatrics, Division of Pulmonary, Allergy and Immunology, Cystic Fibrosis, and Sleep, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-9616-5947
Ashley W WuDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Danniel ZamoraDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Seth M DalyDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Carolyn R SturgeDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Christine PybusDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Bruce L GellerDepartment of Microbiology, Oregon State University, Corvallis, Oregon, USA.
Joanna B GoldbergDepartment of Pediatrics, Division of Pulmonary, Allergy and Immunology, Cystic Fibrosis, and Sleep, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-5285-5188
David E GreenbergDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA david.greenberg@utsouthwestern.edu.ORCID 0000-0002-5101-3106
The University of Texas Southwestern Medical Center · USEmory University · USOregon State University · US

Funding

Advanced development of a viral entry inhibitor as a therapeutic for arenavirus hemorrhagic feverR01AI141102 · NIAID · KINETA, INC. · PI AMBERG, SEAN M · 2019 to 2023
$5.9M
Development of Gene-Silencing Therapeutics for Pseudomonas aeruginosaR01AI141101 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI GREENBERG, DAVID ELIHU · 2019 to 2024
$5.7M
Training Program in Infectious Diseases in the Immunocompromised HostT32AI118690 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BOECKH, MICHAEL J · 2016 to 2025
$4.0M
Gene silencing therapeutics for chronic infections in cystic fibrosisR33AI105980 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI GREENBERG, DAVID ELIHU · 2015 to 2017
$1.1M
NIAID NIH HHS R01 AI141101NIAID NIH HHS R01 AI141102NIAID NIH HHS R33 AI105980NIAID NIH HHS T32 AI118690
6 · The paper itself

Abstract

Most antimicrobials currently in the clinical pipeline are modifications of existing classes of antibiotics and are considered short-term solutions due to the emergence of resistance.

Indexed as

Acyl Carrier ProteinAdministration, InhalationAmidohydrolasesAnimalsAnti-Bacterial AgentsBiofilmsCystic FibrosisDrug Resistance, BacterialFemaleLungMiceMice, Inbred BALB CMicrobial Sensitivity TestsMorpholinosPeptidesPseudomonas aeruginosaAcyl Carrier ProteinAmidohydrolasesAnti-Bacterial AgentsLpxC deacetylase, PseudomonasMorpholinosPeptidesRibosomal Proteinsribosomal protein S30antisenseexperimental therapeuticsPPMOPseudomonas aeruginosa

Identifiers

PMID33436433
PMCPMC7844538
OpenAlexW3119516854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.