Evidence map›Paper›PMID 33436430›Full record

ArticlemBio2021

Functional Differences between E. coli and ESKAPE Pathogen GroES/GroEL.

Jared Sivinski, Andrew J Ambrose, Iliya Panfilenko, Christopher J Zerio, Jason M Machulis, Niloufar Mollasalehi, Lynn K Kaneko, Mckayla Stevens, Anne-Marie Ray, Yangshin Park and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Transcriptome Analysis ofInternational journal of environmental research and public health · 2022
    Article
  3. Article
  4. Allosteric differences dictate GroEL complementation of E. coli.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Jared SivinskiDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Andrew J AmbroseDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Iliya PanfilenkoDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Christopher J ZerioDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Jason M MachulisDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Niloufar MollasalehiDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.
Lynn K KanekoDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
Mckayla StevensDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Anne-Marie RayDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Yangshin ParkDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Chunxiang WuDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Quyen Q HoangDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Steven M JohnsonDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Eli ChapmanDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA chapman@pharmacy.arizona.edu.ORCID 0000-0002-6310-1664
University of Arizona · USIndiana University School of Medicine

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
CHEMISTRY-BIOLOGY INTERFACE TRAINING PROGRAMT32GM008804 · NIGMS · UNIVERSITY OF ARIZONA · PI MONTFORT, WILLIAM R. · 2003 to 2023
$3.9M
Selective modulation of bacterial chaperonins by targeting novel small molecule binding sitesR01GM120350 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI JOHNSON, STEVEN MICHAEL · 2017 to 2021
$2.3M
Molecular bases of leucine rich repeat kinase 2 activity regulationR01GM115844 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HOANG, QUYEN QUOC, YUE, ZHENYU · 2016 to 2019
$2.2M
Structure and Function of the Parkinson's disease associated protein LRRK2R01GM111639 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI HOANG, QUYEN QUOC · 2015 to 2019
$1.6M
NIEHS NIH HHS P30 ES006694NIGMS NIH HHS R01 GM111639NIGMS NIH HHS R01 GM115844NIGMS NIH HHS R01 GM120350NIGMS NIH HHS T32 GM008804
6 · The paper itself

Abstract

As the GroES/GroEL chaperonin system is the only bacterial chaperone that is essential under all conditions, we have been interested in the development of GroES/GroEL inhibitors as potential antibiotics. Using

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsBacterial ProteinsChaperonin 10Chaperonin 60EnterobacterEnterococcus faeciumEscherichia coliGene Knock-In TechniquesGene Knockout TechniquesGram-Negative BacteriaGram-Positive BacteriaKineticsKlebsiella pneumoniaePseudomonas aeruginosaStaphylococcus aureusAnti-Bacterial AgentsBacterial ProteinsChaperonin 10Chaperonin 60antibioticantimicrobialchaperonechaperoninESKAPEGroELGroESHSP10HSP60

Identifiers

PMID33436430
PMCPMC7844535
OpenAlexW3120375612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.