ArticleDiabetes care2021
OGTT Glucose Response Curves, Insulin Sensitivity, and β-Cell Function in RISE: Comparison Between Youth and Adults at Randomization and in Response to Interventions to Preserve β-Cell Function.
Article in Diabetes care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 41 citations in OpenAlex.
- Novel OGTT metrics do not provide incremental predictive value beyond conventional glycemic criteria for remission of prediabetes in individuals with impaired fasting glucose: results from the PREVIEW trial.Cardiovascular diabetology · 2026Trial
- Insulin clearance at randomisation and in response to treatment in youth with type 2 diabetes: a secondary analysis of the TODAY randomised clinical trial.Diabetologia · 2025Trial
- Randomized Controlled Feasibility Trial of Late 8-Hour Time-Restricted Eating for Adolescents With Type 2 Diabetes.Journal of the Academy of Nutrition and Dietetics · 2024Trial
- Shape of the OGTT glucose response curve: relationship with β-cell function and differences by sex, race, and BMI in adults with early type 2 diabetes treated with metformin.BMJ open diabetes research & care · 2021 · on this mapTrial
- Association of the combined triglyceride-glucose and frailty index with chronic kidney disease: evidence from two national cohort studies.Endocrine · 2026Article
- Sex Differences in Combined Effects of Maternal Pre-Pregnancy BMI and OGTT Response Patterns on Early Neurodevelopment in Offspring: A Cohort Study.Journal of diabetes · 2026Article
- Clinical characteristics, disease course, and clinical subgroups of young adults with type 2 diabetes.Journal of the Endocrine Society · 2026Article
- One-Hour Post-Load Glucose Is Associated with Multisystem Complications in People Living with Obesity.Biomolecules · 2026Observational
- Association of Glucose Response Shape in OGTT With Markers of Pancreatic Health and Inflammation Across Diverse Ages.The Journal of clinical endocrinology and metabolism · 2026Article
- The rare glucose response curve during oral glucose tolerance tests in pregnant Chinese women and its association with preterm birth.Archives of medical science : AMS · 2026Article
- The flat glucose response curve during oral glucose tolerance tests in Chinese pregnant women and its association with adverse outcomes.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Observational
- Management of Early-Onset Type 2 Diabetes in Adults: Current Evidence and Future Directions.Diabetes & metabolism journal · 2025Review
- Estimating area under the curve from graph-derived summary data: a systematic comparison of standard and Monte Carlo approaches.BMC medical research methodology · 2025Article
- Insulin resistance in type 2 diabetes mellitus.Nature reviews. Endocrinology · 2025Review
- Association of OGTT-curve Shape With Anthropometric, Metabolic, and Inflammatory Parameters in Healthy Adults.Journal of the Endocrine Society · 2025Article
- Article
- Overview of Pediatric Obesity as a Disease.Pediatric clinics of North America · 2024Review
- Elevated TyG-BMI index predicts incidence of chronic kidney disease.Clinical and experimental medicine · 2024Article
- Youth-onset Type 2 Diabetes: An Overview of Pathophysiology, Prognosis, Prevention and Management.Current diabetes reports · 2024Review
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 1 country.
Funding
Abstract
objectiveWe examined the glucose response curves (biphasic [BPh], monophasic [MPh], incessant increase [IIn]) during an oral glucose tolerance test (OGTT) and their relationship to insulin sensitivity (IS) and β-cell function (βCF) in youth versus adults with impaired glucose tolerance or recently diagnosed type 2 diabetes.RESEARCH DESIGN AND METHODSThis was both a cross-sectional and a longitudinal evaluation of participants in the RISE study randomized to metformin alone for 12 months or glargine for 3 months followed by metformin for 9 months. At baseline/randomization, OGTTs (85 youth, 353 adults) were categorized as BPh, MPh, or IIn. The relationship of the glucose response curves to hyperglycemic clamp-measured IS and βCF at baseline and the change in glucose response curves 12 months after randomization were assessed.RESULTSAt randomization, the prevalence of the BPh curve was significantly higher in youth than adults (18.8% vs. 8.2%), with no differences in MPh or IIn. IS did not differ across glucose response curves in youth or adults. However, irrespective of curve type, youth had lower IS than adults (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.